Reds vs. White Sox, 9/29/21 MLB Predictions & Betting Odds

Reds vs. White Sox MLB Prediction

The White Sox have taken care of business in previous meetings against the Reds, which includes Tuesday night’s victory at Guaranteed Rate Field. Will Chicago knock off Cincinnati again now that the Reds’ postseason hopes are officially over?

Game Snapshot

979 Cincinnati Reds (+150) at 980 Chicago White Sox (-170); o/u 8

8:10 p.m. ET, Wednesday, September 29, 2021

Guaranteed Rate Field, Chicago, IL

Cincinnati Reds DFS Notes

Reds manager David Bell confirmed Tuesday that Jesse Winker (intercostal) is done for the remainder of the regular season. Winker lasted just one game this month before landing back on the IL with ongoing intercostal trouble. The 28-year-old first-time All-Star finishes with a .305/.394/.556 batting line, 24 home runs, 71 RBI, and 77 runs scored in 485 plate appearances. He'll be a very popular name in fantasy drafts next spring.

Chicago White Sox DFS Notes

White Sox manager Tony La Russa said Monday that Carlos Rodon (arm) is still expected to start Wednesday against the Reds. La Russa said Rodon's bullpen session on Sunday went "just OK" and that he didn't pitch at full intensity. Still, the White Sox are going to go ahead and have him pitch anyway. It's obviously incredibly risky from a fantasy perspective and it's hard to know what to expect from him as the White Sox prepare for the playoffs. Rodon felt some renewed soreness in his pitching arm during his most recent start last Monday.

Reds vs. White Sox MLB Betting Prediction

The Reds are 1-6 in their last seven games in Chicago, are 1-5 in their last six road games and are 1-5 in their last six games as an underdog. The White Sox, meanwhile, are 9-1 in their last 10 interleague games, are 5-1 in their last six interleague home games and are 11-4 in their last 15 home games versus an opponent with a winning record.

MLB BETTING PREDICTION: CHICAGO WHITE SOX -170