Giants vs. Padres, 9/22/21 MLB Predictions & Betting Odds

Giants vs. Padres MLB Prediction

The Giants posted yet another come-from-behind victory last night in San Diego but will the slumping Padres rebound when the NL West rivals clash again at 10:10 p.m. ET on Wednesday?

Game Snapshot

911 San Francisco Giants (-120) at 912 San Diego Padres (+100); o/u 9.5

10:10 p.m. ET, Wednesday, September 22, 2021

Petco Park, San Diego, CA

San Francisco Giants DFS Notes

LaMonte Wade went 2-for-5 with an RBI single to help the Giants to a win on Tuesday over the Padres. Wade's RBI single was a big one, as it broke a 5-5 tie and gave the Giants yet another win. The 27-year-old is one of several San Francisco hitters that are having career years, and he's brought home 51 runs with a solid slash of .264/.341/.515 in 98 games.

San Diego Padres DFS Notes

Manny Machado homered twice while going 3-for-5, but the Padres fell to the Giants 6-4 on Tuesday. A terrific baseball game. Machado evened the game at 1-1 in the first with a solo homer off the warehouse against Kevin Gausman, and homered again in the third off Gausman again. He also had a chance to be the hero in the ninth inning, but a hard-hit ball ended up becoming a double play as the Padres continue to unravel in 2021. Machado has gone deep 26 times with 95 RBI, but it looks like his strong season isn't going to help San Diego reach the postseason.

Giants vs. Padres MLB Betting Prediction

The Giants are 23-6 in their last 29 games as a road favorite, are 40-15 in their last 55 road games and are 50-19 in their last 69 games as a favorite. On the other side, the Padres are 1-7 in their last eight games following a loss, are 5-16 in their last 21 games versus division rivals and are 7-22 in their last 29 games as a home underdog.

MLB BETTING PREDICTION: SAN FRANCISCO GAINTS -120