Giants vs. Padres, 9/21/21 MLB Predictions & Betting Odds

Giants vs. Padres MLB Prediction

National League West rivals clash at Petco Park on Tuesday night when the Padres host the Giants at 10:10 p.m. ET. Given San Diego’s struggles, will San Francisco cash for bettors as a slight underdog?

Game Snapshot

961 San Francisco Giants (-105) at 962 San Diego Padres (-115); o/u 7.5

7:10 p.m. ET, Tuesday, September 21, 2021

Petco Park, San Diego, CA

San Francisco Giants DFS Notes

Austin Slater went 1-for-4 and swiped his 15th base of the season on Sunday as the Giants were shut out by the Braves. Slater tallied one of just four total hits -- all singles -- for the Giants against Max Fried and company on Sunday. He's now slashing .229/.312/.395 with 10 homers, 28 RBI and 15 swipes in 298 plate appearances on the season.

San Diego Padres DFS Notes

Tommy Pham homered, doubled and drove in three runs on Sunday in a loss to the Cardinals. Pham did some work against his former club, but it didn't help the Padres avoid being swept by the Cardinals over the weekend. The outfielder has his 14th homer of the season with a solo blast off Alex Reyes, and he drove in two more while adding his 22nd double of the campaign. Pham has had a season of ebbs and flows, and you can see it in a slash of .234/.345/.385.

Padres vs. Giants MLB Betting Prediction

The Giants are 3-7 in their last 10 games in San Diego, but the Padres are 2-8 in their last 10 games overall and are just 1-6 in their last seven games following a loss. They’re also 1-6 in their last seven games following an off day and have dropped five straight when playing the opener of a series. On the other side, the Giants are 39-15 in their last 54 road games and have won 19 of 26 following an off day.

MLB BETTING PREDICTION: SAN FRANCISCO GIANTS -105