Orioles vs. Red Sox, 4/2/21 MLB Betting Predictions & DFS Notes

Orioles vs. Red Sox MLB Prediction

American League East rivals square off at Fenway Park on Friday afternoon when the Red Sox host the Orioles at 2:10 p.m. ET. With John Means set to oppose Nathan Eovaldi in the pitching matchup, what’s the best play in this divisional matchup?

Game Snapshot

929 Baltimore Orioles (+145) at 930 Boston Red Sox (-165); o/u 9

2:10 p.m. ET, Friday, April 2, 2021

Fenway Park, Boston, MA

TV: N/A

Baltimore Orioles DFS Spin

Anthony Santander (oblique) is good to go for Opening Day, per Orioles manager Brandon Hyde. Santander tweaked his oblique last Tuesday, but it turned out to be a relatively minor issue and he should be in the starting lineup for Thursday afternoon's opener against the Red Sox. The 26-year-old outfielder registered an impressive .890 OPS with 11 home runs and 32 RBI in 37 games played last season for Baltimore.

Boston Red Sox DFS Spin

Red Sox manager Alex Cora said Christian Vazquez (eye) is ready for Friday's rescheduled opener. Vazquez will get another day to rest his bruised eye after Thursday's game got rained out. He got struck by a throw late in camp and needed stitches, but it never seemed like an overly serious concern.

Orioles vs. Red Sox Betting Prediction

The over is 3-0-1 in the last four meetings between these two teams in Boston, is 6-1 in the Orioles’ last seven road games and is 5-1 in their last six games overall. The over is also 4-0 in the Red Sox’ last four games as a home favorite, is 4-0 in their last four divisional games and is 6-1-1 in their last eight home games versus a left-handed starter.

MLB BETTING PREDICTION: ORIOLES/RED SOX OVER 9