49ers vs. Saints Week 10 Prediction

49ers vs. Saints, 11/15/20 NFL Week 10 Betting Predictions

Former NFC West rivals meet in New Orleans on Sunday when the Saints host the 49ers at 4:25 p.m. ET. With New Orleans laying 10 points as home chalk and the total sitting at 49 points, what’s the best play for bettors in this matchup?

Game Snapshot

271 San Francisco 49ers (+10) at 272 New Orleans Saints (-10); o/u 49

4:25 p.m. ET, Sunday, November 15, 2020

Venue: Mercedes-Benz Superdome, New Orleans, LA


San Francisco 49ers DFS Spin

49ers head coach Kyle Shanahan said Nick Mullens would remain the team's starting quarterback. Shanny said Mullens was "firmly" the Niners' starter headed into Week 10. Horrifically ineffective for three quarters Thursday night against the Packers, Mullens ended up with a respectable 291 yards and a touchdown thanks to some good old garbage time production. Mullens' up-and-down play has persisted throughout his starts and relief appearances this year, and he should be treated as a fringe option in superflex leagues for the rest of the season.

New Orleans Saints DFS Spin

Drew Brees completed 26-of-32 passes for 222 yards and four touchdowns in the Saints' Week 9 win over the Bucs. The Saints got out to an early lead, with Brees throwing first-half touchdown passes to Emmanuel Sanders, Tre’Quan Smith, and Adam Trautman. Brees managed the game after that, with his lone second-half score going to TE Josh Hill. Brees has been hot over the last three weeks, throwing for 772 yards with no turnovers. He’s on pace for 4,240 yards with a 34:6 TD/INT ratio through the first eight games.

49ers vs. Saints Betting Prediction

The 49ers are 6-1 against the spread in their last seven games versus the Saints and are 4-0 against the number in their last four games in New Orleans. The road team has also covered in five straight series meetings while the underdog is 5-2 against the number in the last seven meetings. The Niners are also 6-2 against the spread in their last eight games as a road underdog, are 6-2 against the number in their last eight road games and are 7-3 ATS in their last 10 games as an underdog. On the other side, the Saints are 1-4 against the spread in their last five home games, are 1-5 against the number in their last six games as a favorite and are 1-5 at the betting window in their last six games coming off a win.


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