Arizona Cardinals vs. San Francisco 49ers, 11/15/19 Predictions & Odds

Cardinals vs. 49ers Total Prediction

Following their first loss of the season, the 49ers will host fellow NFC West rival the Cardinals at 4:05 p.m. ET on Sunday afternoon. Will the game turn into a high-scoring affair or is the under the better play for bettors?

Game Snapshot

467 Arizona Cardinals (+10.5) at 468 San Francisco 49ers (-10.5); O/U 45

4:05 p.m. ET, Sunday, November 17, 2019

Levi’s Stadium, Santa Clara, CA

Public Betting Trends

According to our NFL Football Public Betting Chart page, the Cardinals are receiving 61% of the betting tickets from online sportsbooks.

Arizona Cardinals Fantasy Spin

Kyler Murray completed 27-of-44 passes for 324 yards, three touchdowns and an interception in the Cardinals' 30-27, Week 10 loss to the Bucs, adding three rushes for 38 additional yards. It was arguably Murray's best start of the season, though a few critical mistakes kept it from being perfect. Murray's fourth quarter pick was a bad decision, though it might have merely been an incompletion had Trent Sherfield not fallen down. Murray and coach Kliff Kingsbury then combined for painfully bad clock management on the Cards' final drive. Before that, Murray heated up his connection with Christian Kirk for 6/138/3. TD1 was a 33-yard laser in stride. TD2 was a 69-yard pass down the sideline once again delivered in stride. No. 3 tipped off a linebacker's fingers. Coming off easily his best two-game stretch of the year, Murray gets a Week 11 rematch with the daunting 49ers.

San Francisco 49ers Fantasy Spin

Updating a previous report, George Kittle (knee) has not been formally ruled out for Week 11 against the Cardinals. Coach Kyle Shanahan informed the media that Kittle would be out for Week 11, but he clarified his statement afterward. It's still unlikely that Kittle plays this weekend since he didn't practice on Wednesday, but the door remains somewhat open at the moment. If Kittle is ultimately ruled out, Ross Dwelley will take on Arizona's league-worst defense against tight ends. Kittle owners should definitely have a backup plan for Week 11.

NFL Betting Trends

Arizona

The over is 5-2 in the Cardinals’ last seven games after allowing more than 350 total yards in their previous game.

San Francisco

The over is 4-1 in the 49ers’ last five games after accumulating less than 90 yards rushing in their previous game.

Prediction

The 49ers offense looked less potent without Kittle and Emmanuel Sanders on Monday night and there’s a good chance both players will be unavailable for San Francisco on Sunday. That said, despite missing those two pieces, the 49ers should be fine offensively as long as their running game returns, which it should versus a struggling Arizona defense. On the other side, Robert Saleh’s defense is legit, but that unit also played an extra quarter on Monday night and could be gassed come the second half on Sunday. You don’t want to be trying to chase down Murray with tired legs and that’s the exact scenario the Niners will find themselves in on Sunday. I see this game turning high scoring.

NFL Week 11 Prediction: Cardinals/49ers OVER 45