Colts vs. Titans NFL Prediction

Colts vs. Titans, 9/26/21 NFL Week 3 Betting Predictions & Odds

The Colts will be without Carson Wentz under center when they take on the Titans in Week 3 of the NFL season at 1:00 p.m. ET on Sunday. Does that mean today’s matchup won’t be high-scoring, however?

Game Snapshot

471 Indianapolis Colts (+4.5) at 472 Tennessee Titans (-4.5); o/u 47

1:00 p.m. ET, Sunday, September 26, 2021

Niassan Stadium, Nashville, TN

TV: CBS

Indianapolis Colts DFS Spin

NFL Network's Ian Rapoport reports Carson Wentz (questionable, ankle) is expected to start in Week 3 against the Titans. Wentz "moved around well" at Friday's practice and is on track to start barring a setback. With Wentz dealing with two sprained ankles, it won't be surprising to see the Colts hide Wentz behind a run heavy game script, putting Jonathan Taylor in position for a big Week 3 workload. The Colts will turn to Jacob Eason or Brett Hundley if Wentz is ruled out.

Tennessee Titans DFS Spin

Titans LT Taylor Lewan (knee) is expected to play in Week 3 against the Colts. Lewan missed Week 2 after getting hurt in pre-game warmups. The three-time Pro Bowler has struggled to open the year, giving up four sacks to Cardinals LB Chandler Jones in his lone appearance, but his return is an upgrade for Tennessee's offensive line. Ty Sambrailo will return to a swing role with Lewan healthy.

NFL Week 3 Betting Prediction

The over has cashed in five of the last six meetings between these two teams in Nashville and is 4-1 in the last five meetings between these two teams overall. The over is also 5-2 in the Colts’ last seven games as an underdog, is 6-1 in their last seven road games and is 4-1 in their last five games after allowing more than 350 total yards in their previous game. On the other side, the over is 11-4-1 in the Titans’ last 16 home games, is 7-3-1 in their last 11 games as a home favorite and is 49-19-3 in their last 65 home games versus a team with a losing road record.

NFL WEEK 3 PREDICTION: COLTS/TITANS OVER 47

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