Rams vs. Cardinals Spread Prediction

Los Angeles Rams vs. Arizona Cardinals, 9/16/18 Predictions & Preview

Following their dismal performance at home versus the Redskins last week, the Arizona Cardinals are double-digit road underdog versus the L.A. Rams on Sunday. Will the Cardinals have a bounce-back performance or will the Rams roll?

Game Snapshot

279 Arizona Cardinals at Los Angeles Rams

4:05 p.m. ET, Sunday, September 16

Los Angeles Memorial Coliseum, Los Angeles, CA

Public Betting Trends

According to oddsmakers from online sports book BetNow.eu, the Rams are 13-point favorites to beat the Cardinals. The total, meanwhile, sits at 44.5 points. As of this writing, 61% of the public betting tickets are on the Rams to cover the point spread.

Arizona Cardinals

Christian Kirk is expected to "get more opportunities" in Week 2 against the Rams. This follows comments from coach Steve Wilks earlier this week. Kirk and Chad Williams combined for five targets in the season opener. Kirk's rookie status has him behind Williams in two-wide sets, but we like his chances of overtaking the starting role.

Los Angeles Rams

Rams LB Mark Barron (ankle) is doubtful for Week 2 against the Cardinals. ILB Ramik Wilson and S Marqui Christian will split time in Barron’s stead for the second consecutive week. It's a terrific opportunity for Ricky Seals-Jones on the opposite side of the ball as Raiders TE Jared Cook recorded a ridiculous 9-180 receiving line against the Rams' interim LBs in Week 1. Barron should be considered week-to-week moving forward.

NFL Betting Trends


The Cardinals are 5-20-1 against the spread in their last 26 games after allowing more than 350 total yards in their previous game.

Los Angeles

The Rams are 17-37-1 against the number in their last 55 games played in the month of September.


This point spread feels inflated, especially for a divisional matchup. The Rams are playing on a short week having traveled to Oakland on Monday night and while the Cardinals could do nothing against the Redskins last weekend, I expect a small bounce back today. Arizona isn’t going to pull off a big upset but the Cardinals certainly have enough talent to stay within two touchdowns. I see this as a buy back opportunity with the Cardinals.

NFL Week 2 Prediction: Arizona Cardinals +13

Recent NFL Discussions


NFL Predictions & Picks

Thumbnail NFL Week 4 Betting Report Week 4 features key divisional matchups in Baltimore, Buffalo and Chicago, as well as a pivotal early-season tilt between NFC contenders. Here’s a look at the opening odds...
Thumbnail Rams vs. Browns SNF Prediction The Sunday Night Football matchup has the Rams heading to Cleveland to take on the Browns at 8:20 p.m. ET. Laying 3.5 points as a road favorite, are the Rams...
Thumbnail Steelers vs. 49ers Week 3 Prediction Mason Rudolph will lead the Steelers into Santa Clara on Sunday afternoon in search of the team’s first win. Meanwhile, the 49ers will look to improve to 3-0 on...
Thumbnail Saints vs. Seahawks Week 3 Prediction The Saints won’t have Drew Brees on Sunday when they visit the Seahawks at 4:25 p.m. ET. Will Teddy Bridgewater play better than he did in relief of Brees last...
Thumbnail Texans vs. Chargers Week 3 Prediction The Texans and Chargers both hope to compete for a playoff berth all season and will meet at 4:25 p.m. ET on Sunday in L.A. Which team will walk away with a 1-2...

NFL Headlines