Bills vs. 49ers, 12/6/20 NFL Week 13 Betting Predictions

Bills vs. 49ers Spread Prediction

The 49er opened as 2.5-point underdogs for their Monday night matchup versus the Bills but now San Francisco is a 1-point favorite. Is sharp money backing the 49ers or are the Bills still the better play at 8:15 p.m. ET?

Game Snapshot

485 Buffalo Bills (+1) at 486 San Francisco 49ers (-1); o/u 47

8:15 p.m. ET, Monday, December 6, 2020

Venue: State Farm Stadium, Glendale, AZ

TV: ESPN/ABC

Buffalo Bills DFS Spin

Josh Allen is listed with knee and ankle issues on the Week 13 injury report but practicing in full ahead of Monday night's game against the 49ers. Allen has been picking up some nicks and bruises, but the fact that it is not limiting him in practice is a great sign ahead of a tough matchup with a reviving 49ers defense. Despite San Francisco's improved recent play, Allen's dual-threat ability keeps him locked in as an elite QB1.

San Francisco 49ers DFS Spin

49ers coach Kyle Shanahan said Deebo Samuel (hamstring) "isn't injured" and is "going to be good" for Week 13 against Buffalo. Samuel's missed Thursday practice was a rest day. The 49ers don't want to risk a setback to Samuel, who's the centerpiece of the offense with George Kittle sidelined. Fantasy managers should plan on having Samuel for a Monday night matchup with Buffalo.

Bills vs. 49ers Betting Prediction

The Bills have not ben profitable when facing losing teams, covering just once in their last four opportunities. They’re also 0-3-1 against the number in their last four games played on Monday and are 1-4-1 against the spread in their last six games after allowing more than 350 total yards in their previous contest. The Niners, meanwhile, are 13-3 against the spread in their last 16 appearances on Monday night and are 7-3 against the number in their last 10 home games when facing an opponent with a winning record on the road. The favorite in this series is also 4-1 ATS in the last five meetings.

NFL WEEK 13 BETTING PREDICTION: SAN FRANCISCO 49ERS -1