Bills vs. Colts Prediction

Indianapolis Colts vs. Buffalo Bills, 10/21/18 NFL Predictions & Odds

Can the Indianapolis Colts get themselves on the same page and put together a win when they host the Buffalo Bills today at 1PM ET?

Game Snapshot & Odds

461 Buffalo Bills at 462 Indianapolis Colts

Sunday, October 21, 2018

1PM ET – Lucas Oil Stadium


Compare odds and from multiple different online sportsbooks and shop for the best lines at our new NFL Odds & Betting Page.

Public Betting Trends

According to oddsmakers at, the Colts are the clear favorite at home, as they are getting odds of -7 points against the Bills. The over/under total for the contest is currently listed at 43 points. The public betting for this game currently has 67 percent going on Indianapolis at home. This information is subject to change, however, so be sure to check out our NFL Public Betting Page for updated figures on the game.

Colts losers of four straight

The Indianapolis Colts are riding a four-game losing streak right now following a 42-34 loss to the Jets in New York last week. Indy is now 1-5 on the year, 2-4 against the spread and 4-2 with the over. The Colts have failed to cover in three striaght

The Colts have been moving the ball pretty well this year, averaging 25.3 points and 381.8 yards per contest. Andrew Luck has create the bulk of the offense, throwing for 1,792 yards and 16 touchdowns with eight interceptions. Newly-added tight end Eric Ebron is leading the receiving group with 30 catches for 326 yards and six touchdowns. The Indy run game has produced just 499 yards and one touchdown through six games. Defensively, the Colts are struggling. They are giving up 30 points and 404.5 yards per game. Their pass defense is allowing nearly 300 yards per game.

Bills turning to Anderson

The Buffalo Bills are coming off a tough 20-13 loss at Houston last week to fall to 2-4 on the season. The Bills are also 3-3 against the spread and 4-2 with the under. Buffalo has covered in two straight and three of its last four.

Buffalo has been a mess on offense this year, averaging just 12.7 points and 252.3 yards per game. Their pass game is putting up only 152.8 yards per contest. Rookie Josh Allen has thrown for 832 yards but is out for multiple weeks with an elbow injury. Derek Anderson was signed last week and will be getting the start over the struggling Nathan Peterman. The Buffalo run game is led by LeSean McCoy, who has 243 rushing yards. Defensively, Buffalo is allowing 23 points and 328.5 yards per contest. The Bills have 19 sacks and have forced 19 turnovers.

NFL Betting Trends


The Colts are 30-13 ATS in their last 43 games against a losing team but just 3-7 ATS in their last 10 games following a loss.


Buffalo is 0-5 against the spread in its last five road games against a team with a losing home record and 2-5 ATS in their last seven games on fieldturf.


While the Bills look like a mess on paper, the Colts have been an actual mess all year. They can move the ball, but they are somewhat turnover prone and their defense gives up a lot of big plays. Buffalo may not have the offensive weapons, but their defense has risen to the occasion. They covered on the road last week without Allen playing most of the game and I think Anderson could be a better option than Nathan Peterman anyway. I just can’t trust the Colts to win with some ease against anyone.

NFL Prediction: Buffalo Bills +7

Related: Bills vs. Colts Total Prediction

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