49ers vs. Bills Prediction

NFL Week 6 Predictions: San Francisco 49ers vs. Buffalo Bills 10/16/16

Are the Bills a safe bet to cover as a sizable home favorite today when they host Colin Kaepernick and the 49ers at 1:00PM ET?

According to oddsmakers from online sports book BetDSI, the Bills are 8-point home favorites versus the 49ers while the over/under currently sits at 44.5 points. Buffalo did open as a 7.5-point favorite before the line jumped all the way up to 9. Now it's back down closer to the original number.

Discover an Easy Way to Make Big $$$$! Get 20% off. Call now! 1-866-491-0259

The Niners have been a horrible bet of late, failing to cover in all four of their last four games and going 0-4 against the spread on the road as well. They're also just 2-5 against the number in their last seven games played in the month of October and are 2-8-1 at the betting window in their last 11 games played versus a team with a winning record.

Bet Today's NFL Games

As for the Bills, they're 5-1 against the spread in their last six home games and are 5-2 at the betting window in their last seven games overall. They're 4-1-1 against the number in their last six games coming off a win and 7-3 ATS in their last 10 games after accumulating more than 150 yards rushing in their previous game as well.

NFL Quick Links: Free Matchup Reports|Injuries|Odds Comparison|Scoreboard|Betting Trends

OUR PREDICTION: The Bills have revitalized their running game under new offensive coordinator Anthony Lynn. In their first two games when they went 0-2 under former OC Greg Roman, they scored just 19.0 points per game and averaged 75.5 yards per game on the ground (3.5 per rush). Since Lynn took over, they're 3-0 and have averaged 26.3 PPG, 178.3 rush yards per game, and 5.9 yards per rush. For the season, LeSean McCoy ranks fourth in rushing and should have a field day versus a San Francisco defense that is allowing 146.8 yards per game on the ground this year, which is 31st in the NFL. I like Buffalo's running game to take the game over and for the Bills to eventually pull away.

NFL WEEK 6 PREDICTION: BUFFALO BILLS -8

Loading...

NFL Predictions & Picks

Thumbnail Bills vs. Chiefs Prediction The Bills and Chiefs will play a rematch of last year’s AFC Championship Game when the two teams meet in the Divisional round of the NFL playoffs on Sunday at 6:30 p.m....
Thumbnail Rams vs. Bucs Prediction For the third time in the last two seasons, the Rams and Bucs will meet, only this time the stakes are higher. Will the Rams upset the Bucs for a third consecutive time or is...
Thumbnail 49ers vs. Packers Prediction Aaron Rodgers and the No. 1-seeded Packers will host the 49ers in the Divisional round of the NFL playoffs on Saturday night at 8:15 p.m. ET. Will Rodgers and Co. torch San...
Thumbnail Bengals vs. Titans NFL Prediction Joe Burrow will attempt to do something that no former No. 1 pick has ever accomplished: Advance to a conference championship game in his first or second season....
Thumbnail Cardinals vs. Rams Playoff Prediction The final game of Wild Card Weekend and the first-ever Monday Night Football playoff matchup will take place at SoFi Stadium where the Rams will host the...

NFL Headlines