Cardinals vs. 49ers Total Prediction

Arizona Cardinals vs. San Francisco 49ers, 10/5/18 Predictions & Preview

Can the Arizona Cardinals snap out of their offensive funk this weekend when they go on the road to face the San Francisco 49ers on Sunday at 4:25PM ET?

Game Snapshot & Odds

469 Arizona Cardinals at 470 San Francisco 49ers

Sunday, October 7, 2018

4:25PM ET – Levi’s Stadium


Compare odds and from multiple different online sportsbooks and shop for the best lines at our new NFL Odds & Betting Page.

Public Betting Trends

According to oddsmakers at, the San Francisco is favored at home, as the 49ers are getting odds of -4 points against the Arizona Cardinals. The over/under total is currently listed at 40 points. The public betting for this game currently has 65 percent going on Arizona on the road. This information is subject to change, however, so be sure to check out our NFL Public Betting Page for updated figures on the game.

Cardinals a mess

Arizona is off to an 0-4 start following a 20-17 loss to the Seahawks at home last week. The Cardinals are 2-2 against the spread, covering in their last two, while hitting the under in all four games this year.

The Cardinals have been absolutely putrid on offense this season. They are averaging just 9.3 points and 220.8 yards per game thus far. The rushing attack is putting up only 66.8 yards per game. David Johnson hasn’t gotten on track, as he has 187 rushing yards on 56 carries. Rookie quarterback Josh Rosen has thrown for 216 yards on 19 of 34 passing in limited action as the starter. Defensively, Arizona is allowing 23.5 points and 391.5 yards per game. Their run defense is allowing 141.3 yards per contest.

49ers fall again

The San Francisco 49ers are coming off a 29-27 loss to the Chargers last week in Los Angeles. They are now 1-3 on the season, 1-3 against the spread and 3-1 with the over. The 49ers have hit the over in three straight.

San Francisco is averaging 25 points and 387.5 yards per game this year on offense. The unit didn’t look completely lost without Jimmy Garappolo last week in the loss to the Chargers. C.J. Beathard has thrown for 298 yards and two touchdowns in his place, as Jimmy is out for the rest of the year. Matt Breida has emerged as the lead back for San Francisco. He has 313 yards and a score on 41 carries. Defensively, the 49ers are giving up 29.5 points and 393 yards per game. Their pass defense ranks among the worst in the NFL right now, allowing 288.8 yards per game.

NFL Betting Trends


The Cardinals have hit the under in four straight conference games and in seven straight games on grass.

San Francisco

The 49ers have hit the over in six straight games on grass and in six of their last eight games in October.


Arizona’s offense has a lot of problems and I don’t think going on the road against the 49ers is going to change that. San Francisco is still familiar with a lot of the Cardinals and what they can do and should be ready defensively. San Francisco may be able to ride Breida to some big rushing yards, but I don’t see Beathard picking apart the Arizona secondary. This should be another ugly football game for the Cardinals.


NFL Prediction: Cardinals/49ers Under 40

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