Cardinals vs. Rams, 1/17/21 NFL Wild Card Weekend Betting Predictions

Cardinals vs. Rams Playoff Prediction

The final game of Wild Card Weekend and the first-ever Monday Night Football playoff matchup will take place at SoFi Stadium where the Rams will host the Cardinals at 8:15 p.m. ET. Are the Rams a safe play as a 3.5-point home favorite?

Game Snapshot

151 Arizona Cardinals (+3.5) at 152 Los Angeles Rams (-3.5); o/u 49.5

8:15 p.m. ET, Monday, January 17, 2022

SoFi Stadium, Los Angeles, CA

TV: ESPN/ABC/ESPN+

Arizona Cardinals DFS Spin

DeAndre Hopkins (MCL) will not play in the Cardinals' Wild Card game against the Rams. Hopkins is recovering from knee surgery that was required to deal with a torn MCL. He suffered the initial injury in Week 14. Reports have indicated that the Cardinals would need to make it to the NFC Championship for Hopkins to have a shot at playing in the playoffs. Christian Kirk and A.J. Green will be every-down players until Hopkins retakes the field.

Los Angeles Rams DFS Spin

Matthew Stafford is listed on the Wild Card Round injury report with a toe issue but is practicing in full. It's a new issue for Stafford but evidently not one that is costing him any practice reps. Stafford has had a knack for picking up nicks and bruises the past few seasons, but he didn't miss any games in 2021. Stafford lit up the Cardinals in Week 14 but had an awful home start in Week 4 against the Birds. Much has changed since then, of course.

NFL Wild Card Weekend Betting Prediction

The Cardinals are 1-8-1 against the spread in their last 10 games versus the Rams and are 1-3-1 against the number in their last five games in L.A. The favorite is also 8-2-1 at the betting window in the last 11 meetings between these two teams, while the Rams are 11-4-1 against the spread in their last 16 games coming off a loss and are 28-13-1 against the number in their last 42 games versus conference foes.

NFL WILD CARD WEEKEND BETTING PREDICTIONS: LOS ANGELES RAMS -3.5