Las Vegas NFL Week 16 Point Spread Odds & Over/Under Totals

NFL Week 16 Las Vegas Odds

The majority of the point spreads for Week 16 in the NFL have been posted and there's been line movement on several key matchups.

View NFL Week 16 Odds

Packers at Cardinals, 4:25PM ET, Sunday

Despite losing safety Tyrann Mathieu to a season-ending ACL injury in a win over the Eagles on Sunday night, the Cardinals opened as a 4-point favorite versus the Packers in Vegas this week. The line has climbed to Arizona -4.5 according to oddsmakers from the LV Westgate Superbook, while the over/under sits at 49.5. The Cardinals are still battling with the Panthers for the No. 1 spot in the NFC, while the Packers are in a fight with the Vikings over first place in the NFC North, so this is a key game for both teams.

Panthers at Falcons, 1:00PM ET, Sunday

The banged up Panthers will once again put their undefeated record on the line when they visit NFC South rivals the Falcons this Sunday. Two weeks ago the Panthers routed the Falcons 38-0 in Charlotte, so revenge will be on the minds of Atlanta at the Georgia Dome this weekend. That said, Vegas oddsmakers opened the Panthers at -6.5 and the line has already jumped to a touchdown at most sports books. Clearly oddsmakers aren't buying the Falcons in a revenge spot.

Redskins at Eagles, 8:25PM ET, Saturday

Huge playoff implications will be on the line this Saturday night when the Eagles host the first-place Redskins. Washington can take another step in securing the NFC East with a win, but the Skins are currently a 3-point underdog versus the Eagles after opening as a 4-point underdog. Kirk Cousins has been on fire of late, including last week when he completed 22-of-28 passes for 319 yards and four touchdowns in the Redskins' 35-25 win over the Bills.

NFL Week 16 Las Vegas Odds

101 San Diego Chargers +5.5 (47)

102 Oakland Raiders -5.5

Saturday, December 26

103 Washington Redskins +3 (48)

104 Philadelphia Eagles -3

105 New York Giants +5.5 (44.5)

106 Minnesota Vikings -5.5

107 Chicago Bears +3 (46.5)

108 Tampa Bay Buccaneers -3

109 Carolina Panthers -7 (48)

110 Atlanta Falcons +7

111 Dallas Cowboys +6 (43)

112 Buffalo Bills -6

113 Jacksonville Jaguars +3.5 (52)

114 New Orleans Saints -3.5

115 San Francisco 49ers +8.5 (42.5)

116 Detroit Lions -8.5

117 Cleveland Browns +13 (42)

118 Kansas City Chiefs -13

119 Indianapolis Colts N/A

120 Miami Dolphins N/A

121 New England Patriots -3.5 (46)

122 New York Jets +3.5

123 Houston Texans +4.5

124 Tennessee Titans -4.5

125 Green Bay Packers +4.5 (49.5)

126 Arizona Cardinals -4.5

127 St. Louis Rams +13 (40.5)

128 Seattle Seahawks -13

129 Pittsburgh Steelers -10.5 (47.5)

130 Baltimore Ravens +10.5

131 Cincinnati Bengals +3.5 (40.5)

132 Denver Broncos -3.5

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