NFL Week 16 predictions Archives

Home NFL Week 16 predictions

49ers vs. Colts MNF Week 16 NFL Picks: Will Indy cover as home dog?

A late-December cross-conference matchup brings the 49ers’ playoff-tested machine into Indianapolis to face a Colts team fighting for…

December 21, 2025

Prime-time football returns to Baltimore as the New England Patriots (11-3) — one of the NFL’s hottest teams…

December 21, 2025

The Pittsburgh Steelers (8-6) hit the road to face the Detroit Lions (8-6) in a crucial late-season battle…

December 21, 2025

The Cowboys’ playoff hopes are on life support while the Chargers are hoping to taking another step to…

December 19, 2025

A familiar NFC South rivalry takes center stage in Week 16 as the Tampa Bay Buccaneers travel to…

December 19, 2025

Will the Packers sweep the season series with the Bears when the NFC North rivals clash at 8:20…

December 19, 2025

Is the point spread for Monday night’s Saints vs. Packers matchup set too high? The current number is…

December 23, 2024

Will CeeDee Lamb have a big game against the Bucs when the Cowboys host Tampa Bay on Sunday…

December 22, 2024

The Kirk Cousins era is already over in Atlanta, as the Falcons will start rookie Michael Penix Jr.…

December 22, 2024

Will Lamar Jackson finally end his struggles against the Steelers when the Ravens host their divisional rivals on…

December 21, 2024

Responsible Gaming: For help and resources, visit our Responsible Gaming page or the National Council on Problem Gambling.

Affiliate Disclosure: We may receive affiliate commissions if you sign up through links on our site. Read our full Affiliate Disclosure.