Last Updated on September 11, 2022 12:19 pm by Anthony Rome
Chiefs vs. Cardinals Prediction & Odds
Kyler Murray and the Cardinals find themselves as the underdog on Sunday afternoon, as they’ll host Patrick Mahomes and the Chiefs at 4:25 p.m. ET. Will Arizona cover as the home dog or is there a better bet on the board?
Game Matchup & Betting Odds
471 Kansas City Chiefs (-6.5) at 472 Arizona Cardinals (+6.5); o/u 53.5
4:25 p.m. ET, Sunday, September 11, 2022
State Farm Stadium, Glendale, AZ
Chiefs vs. Cardinals Public Betting Information
Our NFL Public Betting Information page indicates that 52% of public bettors are currently backing the Cardinals when it comes to the spread. This information is subject to change throughout the day, however, so be sure to check the link so you’re receiving the most up-to-date public betting data.
Kansas City Chiefs DFS Spin
JuJu Smith-Schuster (knee) is practicing in full for Week 1 against the Cardinals. Speaking earlier Wednesday, Smith-Schuster said his knee is healthy after it caused him to miss a couple weeks over the summer and in the preseason. He heads into the season as the presumed WR1 in Kansas City and should be loaded into fantasy lineups for Sunday’s shootout with Arizona.
Arizona Cardinals DFS Spin
ESPN’s Adam Schefter reports J.J. Watt is unlikely to play in Week 1 against the Chiefs. Watt didn’t practice at all this week, so his absence from Week 1 was always the likely outcome. He will eye a Week 2 return versus the Raiders. Kansas City’s matchup with Arizona is getting easier by the day. The loss of Watt will make it easier for the Chiefs’ line to keep Patrick Mahomes clean throughout the game. Arizona also lost Rondale Moore on the other side of the ball earlier this week.
Chiefs vs. Cardinals Betting Trends
Chiefs are 8-3 ATS in their last 11 games overall
Home team is 5-1 ATS in their last 6 meetings
Cardinals are 6-1 ATS in their last 7 games as an underdog
Chiefs vs. Cardinals Prediction:
The over is 7-0 in the Chiefs’ last seven games in Week 1, is 4-0 in their last four games as a road favorite and is 7-1 in their last eight games overall. The over is also 17-7 in Kansas City’s last 24 games played in September and 7-1 in its last eight games as a favorite. On the other side, the over is 5-2 in the Cardinals’ last seven games as a home dog.
NFL WEEK 1 PREDICTION: CHIEFS/CARDINALS OVER 53.5