This week’s Big Ten showdown sees the Michigan Wolverines host the Purdue Boilermakers on Saturday, November 1, 2025. According to the latest posted lines, Michigan enters as roughly a -22 point favorite, with the total hovering around 49.0–49.5. In this Purdue vs Michigan prediction, we’ll break down the game information, the market outlook, how the public is leaning, the weather situation in Ann Arbor, and finish with my confident expert pick and final score.
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Game Information
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Matchup: Purdue Boilermakers at Michigan Wolverines
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Date: Saturday, November 1, 2025
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Kickoff: 7:00 PM ET (Michigan Stadium, Ann Arbor)
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Location: Michigan Stadium — Ann Arbor, MI
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TV / Stream: Big Ten Network or regional Big Ten window (check local listings)
Purdue vs Michigan Betting Odds
At Bovada, Michigan is listed at approximately -22 to cover as home favorite, while the over/under total is set near 49.0 (some books showing 49.5) for this matchup. The moneyline reflects Michigan’s heavy favoritism (large negative) with Purdue at a strong underdog price.
Public Betting Information
According to The Spread’s College Football Public Betting Chart, early data indicate that around 65% or more of spread tickets are on Michigan at home in this spot. On the total, the ticket split leans slightly toward the Under 49.0, with about 55–60% of total wagers expecting fewer than 50 points in the game — likely because of Michigan’s tendency to control tempo and dominate on defense in home games.
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Weather Report (Ann Arbor, MI)
The forecast for Ann Arbor on Saturday evening calls for clear to partly cloudy skies, kickoff temperatures around 52-55°F, and light winds under 10 mph. No precipitation is expected, and the conditions will be conducive to standard offensive execution. The controlled environment at Michigan Stadium means weather is unlikely to be a major variable.
Purdue vs Michigan Prediction
Expert Pick: Michigan -22
Michigan has shown strong two-way performance this season and owns a significant home-field edge. Their defense excels in limiting explosive plays and controlling field position, which is critical when facing a Purdue offense that has struggled to sustain drives on the road. In contrast, Purdue has been inconsistent, especially away from home, and has shown weakness executing against disciplined defenses.
Given the disparity in talent and recent performance, Michigan is poised to dominate both lines of scrimmage, enforce its tempo, and build a double-digit lead by halftime. Purdue may keep it competitive in spurts, but the depth gap will tell in the second half.
Final Score Prediction:
Michigan 35 — Purdue 10
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