LSU at Ole Miss Odds, Public Betting & Expert Picks

LSU at Ole Miss headlines Week 5 SEC action Saturday in Oxford (3:30 p.m. ET, ABC). This preview compares opening odds vs. current odds, plus public money, injuries, weather, key betting trends, and our expert pick with buy/sell points. For live updates, check the CFB public betting chart and our College Football hub.

Updated:
September 27, 2025 • 9:20 AM ET

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Game Snapshot

• Matchup: No. 4 LSU Tigers at No. 13 Ole Miss Rebels
• Date/Time: Sat, Sept. 27, 2025, 3:30 p.m. ET
• TV: ABC
• Venue: Vaught–Hemingway Stadium (Oxford, MS)

Opening Odds — LSU at Ole Miss

• Spread: LSU −3.5 (market open Sun)
• Moneyline: LSU −165 / Ole Miss +140
• Total: 61.5
• Notes: Books opened LSU a small road favorite with a high total; early Ole Miss action flipped the line toward the Rebels by midweek.

Current Odds

• Spread: Ole Miss −2.5 (−110) / LSU +2.5 (−110)
• Moneyline: Ole Miss −120 / LSU EVEN
• Total: 57 (O −110 / U −110)
• Move note: LSU −3.5 → Ole Miss −1.5; total trimmed 61.5 → 54.5 (7-point swing to the Under).

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Public Money — Tickets %, Money %, Line Moves

• Tickets % (Spread): Split — LSU holds more tickets, Ole Miss sharper money.
• Money % (Spread): Larger wagers on Ole Miss moved line across zero.
• Total Market: Strong Under money drove total down from 61.5 to 54.5.

Injuries & Weather

• LSU: RB rotation intact; defense healthy entering practice week.
• Ole Miss: WR Jordan Watkins (day-to-day); CB Deantre Prince (questionable).
• Weather: ~83°F, light winds, low rain risk — neutral game conditions.

Trends That Matter

• LSU 5–2 ATS last seven SEC road games.
• Ole Miss 7–1 SU at home since 2024.
• Favorites have covered 5 of last 6 meetings in this rivalry.

Expert Pick & Buy Points

Pick: Under 54.5 — number has dropped hard, but still playable at mid-50s.

• Buy up to: Under 55
• Sell down to: Avoid at 53 or lower
• Alt options: Ole Miss −1.5 if you buy into defensive edge; LSU ML value only if +105+ shows

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