Last Updated on September 26, 2025 10:08 am by Michael Cash
CFB Week 5 injury report & betting impact — verified player statuses for the weeknight slate and every AP Top-25 Saturday matchup, with how those injuries correlate to opening vs. current lines. For live context, open the CFB public betting trends and browse the College Football hub.
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CFB Week 5 Injury Report — Opening vs. Current Line Reads
- Florida State at Virginia (Fri 7:00 ET) — Open: FSU −7, 58.5 • Now: FSU ~−7, 60.5 (total ticked up after clean report).
- TCU at Arizona State (Fri 9:00 ET) — Open: ASU −3, 54.5 • Now: ASU ~−3, 54.5 (attrition priced in early).
- Alabama at Georgia (Sat 7:30 ET) — Open: UGA −3, 53.5 • Now: UGA ~−3, 53.5 (OL injury offsets Bama returns).
- Oregon at Penn State (Sat 7:30 ET) — Open: PSU −6.5, 52.5 • Now: PSU ~−3.5, 52.5 (steam toward Ducks).
- LSU at Ole Miss (Sat 3:30 ET) — Open: MISS −1.5, 56.0 • Now: MISS ~−1.5, 56.5 (offensive health lifts total).
- Ohio State at Washington (Sat 3:30 ET) — Open: OSU −10, 52.5 • Now: OSU ~−8.5, 51.5 (Huskies money despite LB loss).
- USC at Illinois (Sat 12:00 ET) — Open: USC −6.5, 59.5 • Now: USC ~−7, 60.5 (Illini secondary upgrades slowed Trojans steam).
- Notre Dame at Arkansas (Sat 12:00 ET) — Open: ND −6, 64.5 • Now: ND ~−4.5, 63.5 (market fade not injury-driven).
- Georgia Tech at Wake Forest (Sat 12:00 ET) — Open: GT −16.5, 53.5 • Now: GT ~−16.5, 53.5 (flat despite GT absences).
- Indiana at Iowa (Sat 3:30 ET) — Open: IOWA −7.5, 46.5 • Now: IOWA ~−7.5, 46.5 (awaiting B1G report).
- BYU at Colorado (Sat 10:15 ET) — Open: BYU −6.5, 49.5 • Now: BYU ~−7, 49.5 (BYU upgrades, CU DB room thin).
- Arizona at Iowa State (Sat 7:00 ET) — Open: ISU −6.5, 48.5 • Now: ISU ~−6.5, 48.5 (kicker issue affects totals more).
- UMass at Missouri (Sat 7:30 ET) — Open: MIZZ −44.5, 56 • Now: MIZZ ~−44.5, 56.5 (injuries not dictating price).
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College Football Week 5 Injuries — Betting Impact
CFB Week 5 Friday Injury Notes
- Florida State at Virginia — FSU starters cleared, while UVA posted no new outs. Therefore the spread held −7 and totals drifted higher.
- TCU at Arizona State — ASU listed DB Xavion Alford, DE Albert Smith III, and WR Jalen Moss among six absences. Meanwhile TCU traveled healthy. As a result, the market froze at −3 with totals unchanged.
SEC Injury Impact
- Alabama at Georgia — RB Jam Miller and DT Tim Keenan III probable for Bama. Conversely UGA lost RT Earnest Greene III. Consequently, the line stuck near −3 with toggles 2.5–3.5.
- LSU at Ole Miss — LSU’s DE Bryce Reliford out for the year. Ole Miss posted no new absences. Therefore, the line stayed −1.5 and the total ticked upward.
Big Ten & Independent Injury Impact
- Oregon at Penn State — RB Noah Whittington upgraded, WR Evan Stewart still out. PSU remained clean. Thus, early Oregon buy drove −6.5 → −3.5.
- Notre Dame at Arkansas — Irish clean sheet, Arkansas status quo. Yet the line slipped to −4.5 on market drift, not health.
- Indiana at Iowa — B1G availability not yet posted. Consequently, the line froze at −7.5 until Saturday.
- USC at Illinois — USC CB Prophet Brown remains out. Illinois DB unit healthier. Hence, spread moved from −6.5 to −7 with modest total rise.
PAC-12 & Other Top-25 Impact
- Ohio State at Washington — UW LB Taariq Al-Uqdah sidelined. However, money poured on Huskies narrowing OSU −10 → −8.5.
- Georgia Tech at Wake Forest — GT missing DB Savion Riley, RB Chad Alexander, OL Tana Alo-Tupuola, TE Brett Seither. Still, line held double digits.
- BYU at Colorado — BYU’s DE Kini Fonohema and RB Logan Payne upgraded. Conversely CU secondary remains depleted. Consequently, BYU drifted to −7.
- Arizona at Iowa State — ISU kicker out, Arizona no issues. Therefore line stayed −6.5 though total sensitivity increased.
- UMass at Missouri — Mizzou and UMass posted no new injuries. As expected, chalk held at −44.5.
CFB Week 5 Injury Report — Kickoff Weather Windows
- Oregon at Penn State — mid-60s, light wind → totals unaffected.
- Georgia Tech at Wake — elevated rain chance; watch radar before kickoff.
CFB Week 5 Injury Report — Market Reads & Buy/Sell Notes
- Bama-UGA: OL loss vs. RB/DT return balanced → spread glued near −3.
- Oregon-PSU: skill upgrades plus market steam explain 6.5→3.5.
- BYU-CU: BYU upgrades vs. CU thin DB room explain nudge to −7.
- USC-ILL: Illini healthier DBs slowed Trojans steam beyond −7.
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