Last Updated on September 26, 2025 10:08 am by Michael Cash
CFB Week 5 injury report & betting impact โ verified player statuses for the weeknight slate and every AP Top-25 Saturday matchup, with how those injuries correlate to opening vs. current lines. For live context, open the CFB public betting trends and browse the College Football hub.
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CFB Week 5 Injury Report โ Opening vs. Current Line Reads
- Florida State at Virginia (Fri 7:00 ET) โ Open: FSU โ7, 58.5 โข Now: FSU ~โ7, 60.5 (total ticked up after clean report).
- TCU at Arizona State (Fri 9:00 ET) โ Open: ASU โ3, 54.5 โข Now: ASU ~โ3, 54.5 (attrition priced in early).
- Alabama at Georgia (Sat 7:30 ET) โ Open: UGA โ3, 53.5 โข Now: UGA ~โ3, 53.5 (OL injury offsets Bama returns).
- Oregon at Penn State (Sat 7:30 ET) โ Open: PSU โ6.5, 52.5 โข Now: PSU ~โ3.5, 52.5 (steam toward Ducks).
- LSU at Ole Miss (Sat 3:30 ET) โ Open: MISS โ1.5, 56.0 โข Now: MISS ~โ1.5, 56.5 (offensive health lifts total).
- Ohio State at Washington (Sat 3:30 ET) โ Open: OSU โ10, 52.5 โข Now: OSU ~โ8.5, 51.5 (Huskies money despite LB loss).
- USC at Illinois (Sat 12:00 ET) โ Open: USC โ6.5, 59.5 โข Now: USC ~โ7, 60.5 (Illini secondary upgrades slowed Trojans steam).
- Notre Dame at Arkansas (Sat 12:00 ET) โ Open: ND โ6, 64.5 โข Now: ND ~โ4.5, 63.5 (market fade not injury-driven).
- Georgia Tech at Wake Forest (Sat 12:00 ET) โ Open: GT โ16.5, 53.5 โข Now: GT ~โ16.5, 53.5 (flat despite GT absences).
- Indiana at Iowa (Sat 3:30 ET) โ Open: IOWA โ7.5, 46.5 โข Now: IOWA ~โ7.5, 46.5 (awaiting B1G report).
- BYU at Colorado (Sat 10:15 ET) โ Open: BYU โ6.5, 49.5 โข Now: BYU ~โ7, 49.5 (BYU upgrades, CU DB room thin).
- Arizona at Iowa State (Sat 7:00 ET) โ Open: ISU โ6.5, 48.5 โข Now: ISU ~โ6.5, 48.5 (kicker issue affects totals more).
- UMass at Missouri (Sat 7:30 ET) โ Open: MIZZ โ44.5, 56 โข Now: MIZZ ~โ44.5, 56.5 (injuries not dictating price).
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College Football Week 5 Injuries โ Betting Impact
CFB Week 5 Friday Injury Notes
- Florida State at Virginia โ FSU starters cleared, while UVA posted no new outs. Therefore the spread held โ7 and totals drifted higher.
- TCU at Arizona State โ ASU listed DB Xavion Alford, DE Albert Smith III, and WR Jalen Moss among six absences. Meanwhile TCU traveled healthy. As a result, the market froze at โ3 with totals unchanged.
SEC Injury Impact
- Alabama at Georgia โ RB Jam Miller and DT Tim Keenan III probable for Bama. Conversely UGA lost RT Earnest Greene III. Consequently, the line stuck near โ3 with toggles 2.5โ3.5.
- LSU at Ole Miss โ LSUโs DE Bryce Reliford out for the year. Ole Miss posted no new absences. Therefore, the line stayed โ1.5 and the total ticked upward.
Big Ten & Independent Injury Impact
- Oregon at Penn State โ RB Noah Whittington upgraded, WR Evan Stewart still out. PSU remained clean. Thus, early Oregon buy drove โ6.5 โ โ3.5.
- Notre Dame at Arkansas โ Irish clean sheet, Arkansas status quo. Yet the line slipped to โ4.5 on market drift, not health.
- Indiana at Iowa โ B1G availability not yet posted. Consequently, the line froze at โ7.5 until Saturday.
- USC at Illinois โ USC CB Prophet Brown remains out. Illinois DB unit healthier. Hence, spread moved from โ6.5 to โ7 with modest total rise.
PAC-12 & Other Top-25 Impact
- Ohio State at Washington โ UW LB Taariq Al-Uqdah sidelined. However, money poured on Huskies narrowing OSU โ10 โ โ8.5.
- Georgia Tech at Wake Forest โ GT missing DB Savion Riley, RB Chad Alexander, OL Tana Alo-Tupuola, TE Brett Seither. Still, line held double digits.
- BYU at Colorado โ BYUโs DE Kini Fonohema and RB Logan Payne upgraded. Conversely CU secondary remains depleted. Consequently, BYU drifted to โ7.
- Arizona at Iowa State โ ISU kicker out, Arizona no issues. Therefore line stayed โ6.5 though total sensitivity increased.
- UMass at Missouri โ Mizzou and UMass posted no new injuries. As expected, chalk held at โ44.5.
CFB Week 5 Injury Report โ Kickoff Weather Windows
- Oregon at Penn State โ mid-60s, light wind โ totals unaffected.
- Georgia Tech at Wake โ elevated rain chance; watch radar before kickoff.
CFB Week 5 Injury Report โ Market Reads & Buy/Sell Notes
- Bama-UGA: OL loss vs. RB/DT return balanced โ spread glued near โ3.
- Oregon-PSU: skill upgrades plus market steam explain 6.5โ3.5.
- BYU-CU: BYU upgrades vs. CU thin DB room explain nudge to โ7.
- USC-ILL: Illini healthier DBs slowed Trojans steam beyond โ7.
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