Last Updated on September 27, 2025 8:06 am by Michael Cash
CFB Week 5 Best Bets — today’s Saturday card features value angles across the AP Top 25 and marquee TV games. Below we highlight three of the best sides/totals with buy/sell points, plus a couple of long shots worth a look. For live line shifts, keep our CFB public betting chart and College Football hub open for all of our odds, previews and Best Bets for College Football Week 5 games.
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CFB Week 5 Best Bets — Top 3
- LSU −3.5 vs. Ole Miss — Buy up to −4.5; sell down to −3. Ticket count balanced, but LSU’s run-pass balance fits well vs. Rebels’ banged-up secondary.
- Penn State +2.5 vs. Oregon — Buy any +3; sell below +2. Nittany Lions defense matches up with Ducks’ tempo and travel angle. Public leaning Ducks.
- Georgia −10.5 at Kentucky — Buy up to −11; sell below −10. Public on Kentucky but Bulldogs’ trenches set the script. Weather mild; no impact.
CFB Week 5 Long Shots
- Arizona +6 vs. Washington — Buy +7; sell below +5.5. Home field undervalued, Huskies inflated after recent covers.
- Virginia Tech ML (+185) at Miami — Hokies defense trending up; Miami turnover risk keeps outright upset in play.
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Trends & Market Notes
- Underdogs in SEC prime TV spots are 11-4 ATS since last season; LSU/Ole Miss fits the profile.
- Penn State has covered 6 of last 7 as a home dog vs. ranked opponents.
- Georgia is 8-1 ATS on the road following a bye since 2010.
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