Last Updated on September 27, 2025 1:11 pm by Michael Cash
Here’s your real-time look at NFL Week 4 opening odds with spreads, moneylines, totals and quick market notes for every matchup. We’ll keep this updated as numbers adjust. For deeper context, track NFL public betting trends, browse our NFL odds & picks hub, and check weekly SuperContest expert picks.
Saturday AM Market Update — Openers vs. Current
- Overnight picture: Market mostly stable around key numbers; a few half-point trims off 3 and 7. Totals saw light Under interest in several early kickoffs.
- Public tilt: Tickets clustering on a handful of road favorites; sharper buyback showing on some home dogs near +3 and +7.
- Injuries/weather: Limited new clarity; verify inactives 90 minutes pre-kick. Outdoor winds look manageable but worth a final check Sunday morning.
Early Window — Notable Moves
- Vikings vs. Steelers (neutral, London/Dublin): Favorite holding with minor juice swings; total steady. Early public remains on Minnesota, but no key-number break.
- Commanders at Falcons: Favorite flip earlier in the week is intact; small tick toward Atlanta this morning. Total shaved slightly.
- Saints at Bills: Big spread unchanged; total nudged up a touch on Friday and held overnight.
- Panthers at Patriots: New England support continued (fractional add); total trimmed again toward the Under.
- Lions at Browns: Detroit support persisted; total drifted down a half-point with cooler weather reads.
- Titans at Texans: Spread steady at the key; total leaked lower through the week and flattened overnight.
- Giants at Chargers: Chargers a hair higher; total down with light Under interest.
Late Window — Notable Moves
- 49ers at Jaguars: San Francisco trimmed off the opener earlier; total climbed and held (Over interest remains).
- Rams at Colts: Slight buy on Indy at the earlier high; total remains elevated after Friday bump.
- Chiefs at Ravens: Baltimore dipped off -3; market testing -2.5 with resistance around the key. Total unchanged.
- Raiders at Bears: Chicago still the short favorite after the flip; total flat overnight.
Island Games — Status Check
- SNF: Packers at Cowboys: Dallas settled on the key; any move off 7 likely to be brief. Total eased down a tick.
- MNF 1: Jets at Dolphins: Miami holding a field goal; total fractionally higher than mid-week.
- MNF 2: Bengals at Broncos: Denver still north of a touchdown after a small add; total unchanged.
Key Numbers & Buy/Sell Notes
- Keys in play: 3 (BAL-KC, ATL-WSH), 7 (DEN-CIN, DAL-GB). Expect game-day tests of these levels.
- Totals magnets: 45/48 continue to attract two-way action; late steam often follows inactives.
- Actionables: Grab -2.5 on short favorites you like before potential game-day -3; for dogs at +7.5, watch for cheap 7s if favorites take late money.
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Thursday Night Football — Thu, Sept. 25
- Seahawks at Cardinals — 8:15 p.m. ET (Prime Video)
Spread: Seahawks +1.0 (−110) / Cardinals −1.0 (−110) |
Moneyline: SEA −105 / ARI −115 |
Total: 43.5 (O −110 / U −110)
Market note: Near pick’em to start; injury reports could swing the favorite before limits rise.
Looking ahead, we’ve already posted our Seahawks vs. Cardinals TNF betting preview to kick off NFL Week 4.
Dive into our early-week content:
• NFL Week 4 expert picks & consensus card
• NFL Week 4 public betting & market trends
International Game (London) — Sun, Sept. 28
- Vikings vs. Steelers (Tottenham) — 9:30 a.m. ET (NFLN)
Spread: Vikings −2.5 (−125) / Steelers +2.5 (+105) |
Moneyline: MIN −150 / PIT +130 |
Total: 41.0 (O −105 / U −115)
Market note: Neutral field and travel tax; watch WR/OL statuses for the total.
Sunday Early Window — Sun, Sept. 28 (1:00 p.m. ET)
- Panthers at Patriots
Spread: CAR +5.5 (−105) / NE −5.5 (−115) |
Moneyline: CAR +210 / NE −250 |
Total: 43.5 (O −110 / U −110)
Market note: New England taking early respect at home; total sits mid-40s. - Chargers at Giants
Spread: LAC −6.0 (−105) / NYG +6.0 (−115) |
Moneyline: LAC −270 / NYG +220 |
Total: 44.0 (O −105 / U −115)
Market note: Chargers priced as a solid road fave; watch pass-pro injury notes for NYG. - Saints at Bills
Spread: NO +16.5 (−110) / BUF −16.5 (−110) |
Moneyline: NO +775 / BUF −1500 |
Total: 48.0 (O −105 / U −115)
Market note: Big number; totals traders will monitor wind in Orchard Park. - Eagles at Buccaneers
Spread: PHI −3.0 (−110) / TB +3.0 (−110) |
Moneyline: PHI −165 / TB +140 |
Total: 44.5 (O −105 / U −115)
Market note: Early 3 flat; any Bucs injury downgrades could pop to −3.5. - Titans at Texans
Spread: TEN +7.5 (−115) / HOU −7.5 (−105) |
Moneyline: TEN +300 / HOU −400 |
Total: 39.5 (O −110 / U −110)
Market note: Lower total; OL health and pace will drive movement. - Commanders at Falcons
Spread: WAS +2.5 (−110) / ATL −2.5 (−110) |
Moneyline: WAS +120 / ATL −140 |
Total: 45.0 (O −105 / U −115)
Market note: Classic 2.5 opener; any QB upgrade/downgrade could test the 3.
Sunday Late Window — Sun, Sept. 28
- Colts at Rams — 4:05 p.m. ET (CBS)
Spread: IND +3.5 (−115) / LAR −3.5 (−105) |
Moneyline: IND +155 / LAR −180 |
Total: 49.0 (O −105 / U −115)
Market note: Totals opened near 49; indoor setting invites Over interest if both WR rooms trend healthy. - Jaguars at 49ers — 4:05 p.m. ET (CBS)
Spread: JAX +3.5 (−105) / SF −3.5 (−105) |
Moneyline: JAX +155 / SF −180 |
Total: 46.0 (O −110 / U −110)
Market note: Booked under a field-goal/over? Keep an eye on edge-rush vs. protection matchups. - Bears at Raiders — 4:25 p.m. ET (FOX)
Spread: CHI +1.0 (−110) / LV −1.0 (−110) |
Moneyline: CHI −105 / LV −115 |
Total: 48.0 (O −110 / U −110)
Market note: Essentially a pick’em; QB turnover risk will decide side support.
Sunday Night Football — Sun, Sept. 28
- Packers at Cowboys — 8:20 p.m. ET (NBC)
Spread: GB +6.5 (−105) / DAL −6.5 (−115) |
Moneyline: GB +300 / DAL −400 |
Total: 48.0 (O −110 / U −110)
Market note: If Dallas injury news is positive, −7 could appear; Packers money likely at +7 or better.
Monday Night Football — Mon, Sept. 29
- Jets at Dolphins — 7:15 p.m. ET
Spread: NYJ +2.5 (−105) / MIA −2.5 (−115) |
Moneyline: NYJ +125 / MIA −145 |
Total: 45.0 (O −110 / U −110)
Market note: Sitting under a field goal; speed vs. pass rush drives the total. - Bengals at Broncos — 8:15 p.m. ET
Spread: CIN +7.0 (−105) / DEN −7.0 (−115) |
Moneyline: CIN +290 / DEN −380 |
Total: 44.0 (O −110 / U −110)
Market note: Altitude + defense narrative supports the Under crowd; key number at 7 on the side.
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