The Iowa State vs Colorado odds mark one of the weekend’s sharper Power 5 contrasts: the road favorite Cyclones carrying short chalk into Boulder, where Colorado remains volatile in both tempo and defensive metrics. Market confidence sits with Iowa State’s efficiency, but the Iowa State vs Colorado odds have danced around the key number of three as bettors weigh Deion Sanders’ home boost against ISU’s trench edge. Below we unpack opening vs current lines, public splits, injury notes, and buy/sell angles before our pick.
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Iowa State vs Colorado — Date, Time & TV
- Matchup: Iowa State Cyclones at Colorado Buffaloes
- Date/Time: Saturday, Oct 11, 2025 — 3:30 PM ET
- TV: ABC
- Venue: Folsom Field (Boulder, CO)
Iowa State vs Colorado Odds — Open (Oct 8)
- Spread: Iowa State −3 (+100) / Colorado +3 (−120)
- Moneyline: Iowa State −140 / Colorado +120
- Total: 52
- Notes: Market opened near the key three, briefly touching −2.5 and −3.5 on light action before settling back to flat −3; total firm at 52.
Current Odds — Live Board
- Spread: Iowa State −3 (+100) / Colorado +3 (−120)
- Moneyline: Iowa State −140 / Colorado +120
- Total: 52
- Move (open → now): Minimal; respected shops holding −3 on two-way trade.
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Public Betting — Tickets & Money
- Spread: ~62% of tickets on Colorado +3; majority of money on Iowa State −3.
- Total: 54% of tickets on Over 52, but sharper handles to Under after opener.
- Read: Public drawn to Colorado’s home narrative; pros aligned with Iowa State’s road metrics and line discipline near the key number.
Injuries & Matchup Notes
- Iowa State: RB rotation healthy; OL intact. CB depth thin — monitor late designations.
- Colorado: QB Shedeur Sanders probable; OL continuity improved; secondary still banged up at nickel.
- Edge: Cyclones’ defensive front vs Buffaloes’ protection remains the deciding trench factor.
Iowa State vs Colorado Betting Trends
- Iowa State 6–2 ATS in its last eight conference road games.
- Colorado 2–8 ATS vs winning teams since start of 2024.
- Under 5–2 in Buffaloes’ last seven home games above 50 total.
Expert Pick & Buy Points
Pick: Iowa State −3 (+100)
- Buy up to: −3 (even) or better; prefer moneyline at −140 if price climbs.
- Sell down to: −2.5 (−120).
- Total lean: Under 52 if tempo stalls; Over viable only below 51 with early pace confirmed.
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