Clemson vs. Notre Dame, 11/5/22 CFB Betting Odds, Prediction & Trends

Clemson vs. Notre Dame, 11/5/22 CFB Betting Odds, Prediction & Trends Clemson vs. Notre Dame, 11/5/22 CFB Betting Odds, Prediction & Trends

Last Updated on November 5, 2022 4:37 pm by Anthony Rome

Clemson vs. Notre Dame Prediction

No. 4 Clemson will put its unbeaten record and potentially a spot in the postseason on the line when it takes on Notre Dame at 7:30 p.m. ET. Will the Tigers cover as slight favorites or is there a better play on the board when it comes to this matchup in South Bend?

Game Matchup & Betting Odds

421 Clemson Tigers (-3.5) at 422 Notre Dame Fighting Irish (+3.5); o/u 43.5

7:30 p.m. ET, Saturday, November 5, 2022

Notre Dame Stadium, Notre Dame, IN

Clemson vs. Notre Dame Public Betting Information

As of this writing, our CFB Public Betting page shows that 74% of bets are on Clemson. That said, this page is updated frequently so make sure that you click on the link provided so that youโ€™re getting the most updated information.

Clemson Tigers Game Notes

Clade Klubnik completed 2-of-4 passes for 19 yards adding six carries for 15 yards in Saturday’s 27-21 win over Syracuse. Klubnik came in late in the third quarter for DJ Uiagalelei who struggled, turning the ball over three times. Klubnik wasn’t asked to do much but held things down for the Tigers and led two fourth quarter touchdown drives.

Notre Dame Fighting Irish Game Notes

Estime ran for 123 yards to lead Notre Dame in rushing on 20 attempts in the Notre Dame 41-24 win over Syracuse on Oct. 29.

Estime added two touchdowns. It was the second-most rushing yards for the sophomore this season. Estime collected 134 yards on the ground against North Carolina on Sept. 24.

Clemson vs. Notre Dame Betting Trends

Under is 5-1-1 in Tigers last 7 non-conference games

Under is 3-1-1 in Tigers last 5 vs. INDEP

Under is 4-1 in Fighting Irish last 5 home games

Over is 5-2 in Fighting Irish last 7 vs. ACC

Clemson vs. Notre Dame Betting Prediction

Notre Dame is 6-0 against the spread in its last six games versus ACC opponents, is 13-2-1 against the number in its last 16 games played in the month of November and is 9-2 at the betting window in the last 11 games coming off a win. On the other side, the Tigers are just 2-8 against the spread in their last 10 non-conference games and are just 3-8 against the number in their last 11 games following an ATS loss.

COLLEGE FOOTBALL WEEK 10 PREDICTION: NOTRE DAME FIGHTING IRISH +3.5