Last Updated on September 25, 2025 4:21 pm by Michael Cash
Week 4 kicks off in the desert as Seahawks vs. Cardinals odds flip through pick: Arizona opened a short favorite, but the market now backs Seattle with a lower total. Below you’ll find opening vs. current lines, public betting (tickets %), injuries, weather, actionable trends, and our expert picks—organized as quick-hit lists for fast scanning.
🔔 Follow updates: Twitter/X · Bluesky · Facebook
Seahawks vs. Cardinals Game Info & TV
- Date: Thursday, Sept. 25, 2025
- Time: 8:15 p.m. ET
- Location: State Farm Stadium, Glendale, AZ
- TV/Streaming: Prime Video (check local listings)
Opening & Current Odds — Seahawks vs. Cardinals
- Spread: Open: Cardinals -2.5 (-110) · Now: Seahawks -1.5 (-110)
- Total: Open: 44.5 · Now: 43.5
- Moneyline: Open: SEA +120 / ARI -140 · Now: SEA -105 / ARI -115
- Movement snapshot: Side flipped ~4 pts through pick; total nudged lower on Under interest.
💸 Want the best number? Compare live lines before you bet 🏈
Public Betting (Tickets %) — TNF
- Tickets: Seahawks ~62% / Cardinals ~38%
- Read: Seattle support aligns with the flip; watch for late buyback on ARI if +2.5 reappears.
Key Injuries & Weather Watch
- Seahawks: Monitor final statuses at WR and OT; either affects explosive rate and pass-pro.
- Cardinals: Secondary has rotated; CB availability moves the total more than the side here.
- Weather: Indoors (State Farm Stadium). No weather edge; number should trade on personnel/market only.
Betting Trends & Angles
- Prime-time profile: Seahawks have covered two of their last three TNF spots; Arizona 3–1 to the Under in recent prime-time home games.
- Matchup lens: Seattle explosive pass vs. Arizona pressure rate; success hinges on protection more than run game.
- Key numbers: -3 unlikely without fresh Seattle injury news; total toggles around 43/44.
Expert Picks — Seahawks vs. Cardinals
- ATS lean: Seahawks -1.5 (buy to -1 if it shows; pass if it hits -2.5 without +money).
- Total lean: Under 43.5 (prefer 44); dome, but pace/defense suggest a lower ceiling.
- Prop angle: Longest Field Goal Over 47.5 yds (both kickers live indoors; coaching tendency supports attempts).
🏈 Build your TNF card at the best price: Shop lines now 💰
Be first to key line moves & community consensus.
Join the forum, claim your handle, and get our best content by email.
Responsible Gaming
If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER. Set limits and play responsibly.
Affiliate Disclosure
Some links on this page are affiliate links. We may earn a commission if you sign up through our links. This helps support our coverage at no cost to you.