Cardinals vs. Indians MLB Prediction

Cardinals vs. Indians, 7/27/21 MLB Betting Predictions & DFS Notes

Interleague play heads to Cleveland this week when the Indians host the Cardinals at 7:10 p.m. ET on Tuesday night. With Adam Wainwright set to oppose Cal Quantrill in the pitching matchup, is St. Louis a safe bet to cash in the series opener?

Game Snapshot

973 St. Louis Cardinals (-100) at 974 Cleveland Indians (-110); o/u 9

7:10 p.m. ET, Tuesday, July 27, 2021

Progressive Field, Cleveland, OH

St. Louis Cardinals DFS SPIN

Tyler O'Neill went 2-for-3 with a two-run homer on Sunday, powering the Cardinals to a 10-6 victory over the Reds. O'Neill set the tone early with a colossal two-run blast to center field -- his 17th round-tripper of the season -- off righty Sonny Gray in the opening frame. The 26-year-old burgeoning five-category fantasy superstar has put together a legitimate breakthrough campaign, slashing .274/.331/.526 with 42 runs scored, 17 homers, 40 RBI and eight stolen bases across 296 plate appearances this season.

Cleveland Indians DFS Spin

Cesar Hernandez went 2-for-4 with a solo homer on Sunday as Cleveland edged the Rays 3-2 at Progressive Field. Hernandez put Cleveland on the scoreboard with an impressive opposite-field shot versus southpaw Ryan Yarbrough in the opening frame. The 31-year-old second baseman has gone deep six times across 21 games since June 30. He's a decent source of over-the-fence power for fantasy managers in deeper mixed leagues and AL-only formats.

Cardinals vs. Indians Betting Prediction

The Cardinals are just 1-6 in their last seven games following an off day, are 1-5 in their last six interleague road games and are 2-6 in their last eight games versus American League Central opponents. The Indians, meanwhile, are 4-1 in their last five interleague home games, are 43-18 in their last 61 games as a home favorite and are 11-5 in their last 16 games as a favorite.

MLB BETTING PREDICTION: CLEVELAND INDIANS -110

Loading...

MLB Headlines

MLB Predictions & Picks

Thumbnail Red Sox vs. Astros ALCS Game 1 Pick Game 1 of the ALCS is set for 8:07 p.m. ET on Friday when the Astros host the Red Sox on FOX. With Chris Sale set to oppose Framber Valdez, which side has the edge...
Thumbnail Dodgers vs. Giants Game 5 Prediction It all comes down to Thursday night in San Francisco when the Giants host their bitter rivals the Dodgers for Game 5 of the NLDS at 9:07 p.m. ET. Which team will...
Thumbnail Giants vs. Dodgers Game 4 Prediction The Giants are on the verge of eliminating the Dodgers and punching their ticket to the NLCS following their 1-0 win in Game 3 of the NLDS on Monday night. Is San...
Thumbnail Brewers vs. Braves Game 4 Prediction The Braves can eliminate the Brewers in Game 4 of the NLDS at 5:15 p.m. ET on Tuesday. With Charlie Morton set to face the Brewers for a second time in this...
Thumbnail Astros vs. White Sox Game 4 Prediction The White Sox staved off elimination by breaking out the bats last night in their rout of the Astros in Game 3. Will Chicago now even its series with Houston...