Cardinals vs. Indians, 7/27/21 MLB Betting Predictions & DFS Notes

Cardinals vs. Indians MLB Prediction

Interleague play heads to Cleveland this week when the Indians host the Cardinals at 7:10 p.m. ET on Tuesday night. With Adam Wainwright set to oppose Cal Quantrill in the pitching matchup, is St. Louis a safe bet to cash in the series opener?

Game Snapshot

973 St. Louis Cardinals (-100) at 974 Cleveland Indians (-110); o/u 9

7:10 p.m. ET, Tuesday, July 27, 2021

Progressive Field, Cleveland, OH

St. Louis Cardinals DFS SPIN

Tyler O'Neill went 2-for-3 with a two-run homer on Sunday, powering the Cardinals to a 10-6 victory over the Reds. O'Neill set the tone early with a colossal two-run blast to center field -- his 17th round-tripper of the season -- off righty Sonny Gray in the opening frame. The 26-year-old burgeoning five-category fantasy superstar has put together a legitimate breakthrough campaign, slashing .274/.331/.526 with 42 runs scored, 17 homers, 40 RBI and eight stolen bases across 296 plate appearances this season.

Cleveland Indians DFS Spin

Cesar Hernandez went 2-for-4 with a solo homer on Sunday as Cleveland edged the Rays 3-2 at Progressive Field. Hernandez put Cleveland on the scoreboard with an impressive opposite-field shot versus southpaw Ryan Yarbrough in the opening frame. The 31-year-old second baseman has gone deep six times across 21 games since June 30. He's a decent source of over-the-fence power for fantasy managers in deeper mixed leagues and AL-only formats.

Cardinals vs. Indians Betting Prediction

The Cardinals are just 1-6 in their last seven games following an off day, are 1-5 in their last six interleague road games and are 2-6 in their last eight games versus American League Central opponents. The Indians, meanwhile, are 4-1 in their last five interleague home games, are 43-18 in their last 61 games as a home favorite and are 11-5 in their last 16 games as a favorite.

MLB BETTING PREDICTION: CLEVELAND INDIANS -110