The Seattle Seahawks visit the Arizona Cardinals on Sunday, September 20, 2026, and the spread has tightened since the number first went up. Seattle is a 4-point road favorite at State Farm Stadium. A week ago this looked like a mismatch. It does not anymore. Both teams are 1-0. Arizona won at Los Angeles in Mike LaFleur’s head coaching debut, while Seattle rallied past New England without its starting quarterback. Now the Seahawks travel to Glendale without Sam Darnold, and the market has nudged toward the home underdog. Below is the full breakdown of the spread, the moneyline, the total, the line movement and the public betting split.
Last Updated: September 19, 2026
Seattle Seahawks vs. Arizona Cardinals — Time & How to Watch
| Where | State Farm Stadium, Glendale, AZ |
| When | Sunday, September 20 – 4:25 PM ET |
| TV | FOX |
Seattle Seahawks vs. Arizona Cardinals Matchup Overview
Seattle opened the season with a 13-10 win over New England on September 9. The night turned early. Darnold went down with a glute injury five plays into the game, and Drew Lock finished it. Lock completed 16 of 22 passes for 187 yards and a touchdown. The defense did the rest. Seattle picked off Drake Maye three times in the fourth quarter alone, with Nehemiah Pritchett, Julian Love and Josh Jobe each grabbing one. Jaxon Smith-Njigba caught eight passes for 122 yards, including the 45-yard score that flipped the game. Our Patriots vs. Seahawks odds preview covered that opener in full.
Arizona’s opener was the bigger surprise. The Cardinals went into SoFi Stadium and beat the Chargers 26-14. Jacoby Brissett completed 27 of 37 attempts for 277 yards and a touchdown in his first start under LaFleur. Rookie running back Jeremiyah Love, the No. 3 overall pick, scored on a 5-yard run. Arizona sacked Justin Herbert three times and picked him off once. We previewed that game in our Cardinals vs. Chargers prediction.
The quarterback news is the headline here. Seattle ruled Darnold out for Week 2 and named Lock the starter. Head coach Mike Macdonald said the team does not plan to place Darnold on injured reserve and will evaluate him day by day. Arizona has its own bumps but nothing at the same level. Guards Isaiah Adams and Isaac Seumalo, defensive tackle Roy Lopez and cornerbacks Max Melton and Garrett Williams all appeared on the Cardinals injury report during the week. Tight end Trey McBride, safety Budda Baker and edge rusher Josh Sweat were listed for rest rather than injury.
History leans toward Seattle. The Seahawks swept the season series a year ago, winning 23-20 in Arizona and 44-22 at home. However, this is a new Cardinals staff and a new quarterback. The 2025 results tell you less than usual.
Seattle Seahawks vs. Arizona Cardinals Odds
| Spread | Moneyline | Total | |
|---|---|---|---|
| Seahawks | -4 (-105) | -200 | O 41 (-110) |
| Cardinals | +4 (-115) | +170 | U 41 (-110) |
Odds accurate as of September 19, 2026 via TheSpread.com. Odds change, get the latest NFL Odds – Futures – Props
Seattle Seahawks vs. Arizona Cardinals — Who Is the Public Betting?
| Seahawks | 59% | 41% | Cardinals |
See the latest NFL Public Betting Splits and make smarter wagers!
NFL Betting Angle for Seattle Seahawks vs. Arizona Cardinals
The spread opened at Seahawks -4.5 and now sits at -4. That is a small move, but the direction matters. The moneyline tells the same story. Seattle opened at -225 and has shortened to -200, while Arizona has gone from +185 to +170. Money has come in on the home side. Meanwhile, 59 percent of spread tickets are on Seattle. The split is not extreme, and it does not clear the 70 percent threshold that usually signals a public overload. Still, the majority of bets sit on one team while the number drifts the other way. That is the classic shape of sharper money taking the points.
The case for Seattle is straightforward. The Seahawks are the better roster and the better defense, and Week 1 showed they can win a close game with their backup under center. Lock posted a 113.3 passer rating against New England without a turnover. Arizona’s line held up against the Chargers, but Seattle’s front is a different weekly problem.
The case for Arizona rests on price. Four points is a short number for a home underdog, and +4 at -115 in a division game has value if you believe the Cardinals are a real team. LaFleur’s offense produced a clean, mistake-free opener against a quality front. In contrast, the counterargument is simple. One road win over a Chargers team that turned it over on downs three times is a thin sample.
The total is the quieter market. It opened at 40.5 and has crept to 41 with even juice on both sides. That is a low number by modern standards. Seattle’s opener produced 23 combined points, while Arizona’s produced 40. A Seattle offense led by a backup, against a defense that just held the Chargers to 14, argues for the under. The other side is that both offenses moved the ball efficiently in Week 1.
Drew Lock and the Seahawks Offense Without Sam Darnold
Everything about this line runs through the Seattle quarterback room. Darnold’s absence is the reason a road favorite in a division game is only laying four points.
Week 1 offered a partial answer. Lock entered on the first drive, so he played essentially a full game. He was efficient and he protected the ball. He also leaned on the same weapons Darnold would have used. Smith-Njigba produced a 122-yard afternoon, and Cooper Kupp added a 25-yard catch that set up a field goal. Kupp practiced all week despite a back issue, per the Seahawks injury report.
The caveat is volume. Seattle scored 13 points, and the defense won that game with three fourth-quarter takeaways. If Arizona protects the ball the way it did in Los Angeles, Seattle may not get the same short fields. That is the pressure point for a 4-point road favorite. On the other hand, Lock now gets a full practice week as the starter rather than a mid-drive promotion.
NFL Seahawks vs. Cardinals FAQ: Sunday September 20, 2026
What time does the Seahawks vs. Cardinals game start?
Kickoff is 4:25 PM ET on Sunday, September 20, 2026. That is 1:25 PM local time in Arizona, which stays on Mountain Standard Time year-round. The game sits in the late Sunday afternoon Week 2 window, and both teams enter at 1-0.
What channel is the Seahawks vs. Cardinals game on?
The game airs on FOX. Chris Myers handles play-by-play with Mark Schlereth on color analysis and Megan Olivi reporting from the sideline. Both clubs list the same crew on their official game-week pages. On radio, Seattle Sports 710 AM carries the Seahawks call and Arizona Sports 98.7 FM carries the Cardinals side.
Where are the Seahawks and Cardinals playing?
The game is at State Farm Stadium in Glendale, Arizona, the Cardinals’ home venue in the Phoenix metro area. Seattle is the road team in this Week 2 NFC West matchup. Arizona opened the season at the Chargers, so this is the Cardinals’ first home game of 2026.
Who is starting at quarterback for the Seahawks and Cardinals?
Drew Lock starts for Seattle with Sam Darnold ruled out because of a glute injury. Jacoby Brissett starts for Arizona after leading the Cardinals to a 26-14 win at the Chargers in Week 1. Jalen Milroe is listed as Seattle’s backup.
Who won the last meeting between the Seahawks and Cardinals?
Seattle won the last meeting 44-22 on November 9, 2025, at home. The Seahawks also won the earlier 2025 matchup in Arizona 23-20, completing a season sweep and outscoring the Cardinals 67-42 across the two games. Sunday is the first meeting of the 2026 season series.