The New York Giants carry a 1-0 record and a fast-starting young quarterback across the country for Monday Night Football against the Los Angeles Rams at SoFi Stadium. The Rams are 6.5-point home favorites after opening at -7, and the total sits at 47.5. Los Angeles is looking to bounce back from a lopsided Week 1 loss, but it will do so without its top offseason addition on defense. Below, we break down the matchup and where we see value on the spread and total.
Last Updated: Monday, September 21, 2026
New York Giants vs. Los Angeles Rams — Time & How to Watch
| Where | SoFi Stadium, Inglewood, CA |
| When | Monday, September 21 – 8:15 PM ET |
| TV | ESPN, ABC |
New York Giants vs. Los Angeles Rams Betting Preview
The Giants opened the John Harbaugh era with a 28-20 win over Dallas. Jaxson Dart was efficient throughout. He completed 23 of 29 passes for 230 yards and three touchdowns with no interceptions, and he added 54 rushing yards. Isaiah Likely caught eight passes for 78 yards and two scores in his Giants debut. Meanwhile, Cam Skattebo ran for 81 yards and a touchdown on 18 carries, and Malik Nabers chipped in six catches for 69 yards.
The Rams had a much rougher start. San Francisco beat them 27-7 in Melbourne, Australia. Los Angeles was stopped on a fourth-and-goal from the 1-yard line, and Matthew Stafford threw an interception. That is a jarring result for the reigning 2025 AP NFL MVP, who led the league with 4,707 passing yards and 46 touchdown passes last season.
Injuries are the bigger story for Los Angeles. Myles Garrett, acquired from Cleveland this offseason, underwent knee surgery and landed on injured reserve. He will miss at least four games. Puka Nacua is questionable with a hip issue, and Sean McVay said his availability was still to be determined. In addition, safety Kamren Kinchens is out and receiver Jordan Whittington is doubtful. For New York, cornerback Deonte Banks and linebacker Micah McFadden are both questionable.
History favors the home side. The Rams lead the regular-season series 29-16, and they won the last meeting 26-25 at MetLife Stadium in Week 17 of the 2023 season.
New York Giants vs. Los Angeles Rams Odds
| Spread | Moneyline | Total | |
|---|---|---|---|
| Giants | +6.5 (-105) | +260 | U 47.5 (-105) |
| Rams | -6.5 (-115) | -320 | O 47.5 (-115) |
Odds accurate as of Monday, September 21, 2026 via TheSpread.com. Odds change, get the latest NFL Odds – Futures – Props
New York Giants vs. Los Angeles Rams — Who Is the Public Betting?
| Giants | 57% | 43% | Rams |
See the latest NFL Public Betting Splits and make smarter wagers!
Giants vs. Rams Prediction — Is a Touchdown Cushion Still Too Much?
This number has already moved toward New York. The spread opened at Rams -7 and has dipped to -6.5, with the juice now shaded toward Los Angeles. That half point matters, because a seven-point Rams win would now cash for Giants backers instead of landing as a push. Spread tickets lean toward the Giants at 57 percent, but that is not lopsided enough to call this a public-fade spot.
The case for the road dog starts with Garrett’s absence. The Rams traded for him this offseason, and now their front must get home without him. Dart showed in Week 1 that he can move the chains with his arm and his legs. Nacua’s uncertain status also removes Stafford’s most dependable target from an offense that managed only one touchdown in its opener. Add Brian Burns, who ranked second in the league with 16.5 sacks last season, and New York has a real path to keeping this close.
Still, the case against is strong. Stafford is the reigning MVP, and one poor showing after a long trip overseas may say little about his form at home. The Rams have won the last meeting in this series, and a young quarterback on a cross-country Monday night road trip is a spot where mistakes can pile up. Even so, we trust the matchup edges and the extra half point more than the market’s respect for last season’s Rams. For more on the number itself, see today’s Giants vs. Rams odds and spread breakdown.
The Pick: Giants +6.5 (-105)
Giants vs. Rams Prediction — Which Offense Controls the Clock?
The total opened at 48 and has slipped to 47.5. New York’s Week 1 offense won with efficiency rather than big plays. Dart completed 23 of 29 throws, and Skattebo handled 18 carries. That kind of methodical attack tends to shorten games. On the other side, the Rams scored just seven points in Melbourne, and they may be without Nacua again. Fewer possessions and a banged-up receiver room both point in the same direction.
However, there is a real case for points. Stafford threw 46 touchdown passes last season, and he is back at home after a long trip to Australia. The Rams’ defense is also weaker without Garrett, which could let Dart keep drives alive. Still, we lean toward a slower, more physical game than the market expects.
The Pick: Under 47.5 (-105)
Final Thoughts and Bonus Angle
If you like the Giants to cover, the moneyline deserves a look for a smaller stake. At +260, the price implies roughly a 28 percent chance of an outright upset. New York won its opener without trailing, while Los Angeles enters with a missing star pass rusher and a questionable top receiver. On the other hand, Stafford at home remains a tough out, so this is a sprinkle rather than a primary position.
Bonus Pick: Giants Moneyline (+260)
Here is a recap of our picks for Giants vs. Rams on Monday night:
- Giants +6.5 (-105)
- Under 47.5 (-105)
- Giants Moneyline (+260)
NFL Giants vs. Rams FAQ: Monday September 21, 2026
What time does the Giants vs. Rams game start?
The Giants vs. Rams game kicks off at 8:15 PM ET on Monday, September 21, 2026, which is 5:15 PM local time in Los Angeles. The game is played at SoFi Stadium in Inglewood, California, as part of the NFL’s Week 2 schedule.
What channel is the Giants vs. Rams game on?
The Giants vs. Rams game airs nationally on ESPN and ABC as the Week 2 edition of Monday Night Football. Joe Buck will call the play-by-play with Troy Aikman as the analyst, and coverage begins with the 8:15 PM ET kickoff from SoFi Stadium.
How can I stream the Giants vs. Rams game?
You can stream the Giants vs. Rams game on NFL+, which carries the broadcast on phones and tablets. Both the Giants and Rams list NFL+ as the streaming option for this Monday night matchup, which kicks off at 8:15 PM ET from SoFi Stadium in Inglewood.
Who won the last meeting between the Giants and Rams?
The Rams won the last meeting 26-25 over the Giants at MetLife Stadium in East Rutherford, New Jersey, in Week 17 of the 2023 season. Los Angeles also leads the all-time regular-season series 29-16, and Monday’s game is the 46th regular-season meeting between the two franchises.
What are the Giants’ and Rams’ records this season?
The Giants are 1-0 after beating the Dallas Cowboys 28-20 in Week 1, and the Rams are 0-1 after losing 27-7 to the San Francisco 49ers in Melbourne, Australia. New York’s victory came in John Harbaugh’s debut as head coach, and Monday’s game is Week 2 for both teams.