Colts vs. Broncos Prediction: Can Broncos stay in playoff mix?

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The Indianapolis Colts head to Denver to face the Broncos on Sunday when Week 15’s late slate begins at 4:25 PM ET on CBS. Can the Broncos cover the 4-point spread as home favorites? Keep reading for our Colts vs. Broncos betting prediction.

The Indianapolis Colts are 6-7 straight up and 8-5 against the spread this year. Their best win came against Pittsburgh, and their worst loss came against Jacksonville.

The Denver Broncos are 8-5 straight up and 10-3 against the spread this season. Their best win came against Tampa Bay, and their worst loss came against the Chargers.

Colts vs. Broncos Matchup & Betting Odds

473 Indianapolis Colts (+4) at 474 Denver Broncos (-4); o/u 43.5

4:25 p.m. ET, Sunday, December 15, 2024

Empower Field at Mile High, Denver, CO

TV: CBS

Colts vs. Broncos Public Betting Information

Our NFL Public Betting Information page indicates that 61% of public bettors are currently backing the Broncos when it comes to the spread. This information is subject to change throughout the day, however, so be sure to check the link so you’re receiving the most up-to-date public betting data.

Indianapolis Colts Daily Fantasy Spin

Colts offensive tackle Braden Smith (personal), wide receiver Ashton Dulin (ankle), and cornerback JuJu Brents (knee) will all miss Sunday’s road clash with the Broncos. Third-round rookie Matt Goncalves will likely start at right tackle in Smith’s place this weekend.

Indianapolis defensive end Tyquan Lewis (ribs), linebacker Jaylon Carlies (lower leg), wide receiver Josh Downs (shoulder), and tight end Mo Alie-Cox (hip) are all officially listed as questionable to play this weekend. Carlies will likely be a game-time decision while Alie-Cox is expected to play on Sunday.

Denver Broncos Daily Fantasy Spin

Broncos starting right cornerback Riley Moss will miss Sunday’s home date with the Colts due to a knee injury. Moss has 71 total tackles, an interception, and 8 passes defended this season. He’ll likely be replaced in the starting lineup by fifth-round rookie Kris Abrams-Draine on Sunday.

Denver rookie quarterback Bo Nix has played well in his first NFL season. The #12 overall pick out of Oregon has thrown for 2,842 yards, 17 touchdowns, and 8 interceptions and run for 304 yards and 4 touchdowns in 13 games of action this year. Nix’s total QBR of 56.1 is tied for 20th in the NFL this season.

Indianapolis is 7-3 ATS in their last 10 games against Denver.

Indianapolis is 6-3 ATS as an underdog this season.

Denver is 10-12-1 ATS as a favorite since the start of the 2022 season.

Denver is 11-12 ATS as the home team since the beginning of the 2022 season.

Colts vs. Broncos Betting Prediction:

The Colts have been solid against the number in several different situations over the past few seasons. Indianapolis is 8-6 ATS after a win and 8-6 ATS as the road team since the start of last season. What’s more, the Colts are 4-0 ATS after a bye and 15-10 ATS as a road underdog since the start of the 2020 season. In Indy’s last 5 games against the Broncos in Denver, the Colts are 3-2 straight up and 4-1 against the spread. The public seems to like the Broncos in this game, but I don’t. I’m taking Indianapolis and the points on the road in Denver on Sunday afternoon.

NFL Week 15 Colts vs. Broncos Betting Prediction: INDIANAPOLIS COLTS +4