The Indianapolis Colts limp into EverBank Stadium on Sunday, November 1, 2026, as 10-point underdogs against the AFC South-leading Jacksonville Jaguars. This number has moved hard since it opened. Indianapolis has dropped three straight games, and this week it traded away two franchise cornerstones. Jacksonville, meanwhile, comes off a bye and owns a long home winning streak in this series. Below, we break down the latest odds, the line movement, and our best bets for the side and the total, including whether the market has pushed this spread too far.
Last Updated: Sunday, November 1, 2026
Indianapolis Colts vs. Jacksonville Jaguars — Time & How to Watch
| Where | EverBank Stadium, Jacksonville, FL |
| When | Sunday, November 1 – 1:00 PM ET |
| TV | CBS |
Indianapolis Colts vs. Jacksonville Jaguars Betting Preview
Indianapolis sits at 2-5 and has lost three in a row. The latest defeat was a 16-10 loss at Minnesota, where the offense managed just one touchdown. That skid followed a decent start to the season. However, the front office signaled a new direction on Tuesday. The Colts traded All-Pro guard Quenton Nelson to Seattle and sent defensive tackle DeForest Buckner back to San Francisco on the same day. Both moves returned draft picks. Both also remove a top player from each line of scrimmage.
Daniel Jones remains the starting quarterback. Head coach Shane Steichen stuck with him this week despite a rough stretch. Ball security is the biggest concern. Indianapolis carries a -9 turnover margin, among the worst marks in the league. On the injury front, cornerback Sauce Gardner returned to full practice after missing time with a calf injury.
Jacksonville enters at 4-2 and in first place in the AFC South. The Jaguars won three straight before a 34-31 loss to Houston in London. Trevor Lawrence threw for 306 yards and four touchdowns in that game, and he now comes off a bye. The Jaguars will be without safety Antonio Johnson, who was ruled out with an ankle injury. History also favors the home side. Jacksonville swept both meetings last December, and the Colts have not won in Jacksonville since 2014.
Indianapolis Colts vs. Jacksonville Jaguars Odds
| Spread | Moneyline | Total | |
|---|---|---|---|
| Colts | +10 (-110) | +360 | O 46.5 (-110) |
| Jaguars | -10 (-110) | -470 | U 46.5 (-110) |
Odds accurate as of Sunday, November 1, 2026 via TheSpread.com. Odds change, get the latest NFL Odds – Futures – Props
Indianapolis Colts vs. Jacksonville Jaguars — Who Is the Public Betting?
| Colts | 43% | 57% | Jaguars |
See the latest NFL Public Betting Splits and make smarter wagers!
Colts vs. Jaguars Prediction — Has the Market Overcorrected on Indy?
This spread opened with Jacksonville laying 7.5 points. It now sits at 10, a move of 2.5 points that crosses several meaningful margins. The moneyline followed, stretching from -400 to -470 on the Jaguars. The trades explain much of that shift. Losing Nelson weakens the interior protection in front of Jones. Losing Buckner thins a run defense that already struggles. The market is pricing the Colts as a team in sell-off mode.
Still, the price matters more than the narrative. Indianapolis lost each of its last two games by six points, 26-20 to Tennessee and 16-10 at Minnesota. Both results would have covered a 10-point number. Jacksonville’s last two games were also tight. The Jaguars beat Philadelphia 19-17 on a 57-yard field goal, then lost to Houston by three. In other words, the Jaguars have not routinely blown out quality opponents. The public split is fairly balanced, with 57 percent of spread bets on Jacksonville. That suggests the move came from more than casual money, but it also leaves no strong crowd to fade.
The case against Indianapolis is real. Jacksonville is rested, at home and has dominated this series in Florida. Jones’ turnover issues could hand the Jaguars short fields and turn a close game into a rout. If Lawrence carries his London form into this game, the Colts may not keep pace. However, double-digit spreads demand a lot from a team that has played mostly one-score games. We prefer taking the points after the move.
The Pick: Colts +10 (-110)
Colts vs. Jaguars Prediction — Can a Reshuffled Colts Offense Push the Pace?
The total has not budged from its opening number of 46.5, even as the spread moved. That stability is telling. Jacksonville games have gone under in four of six contests this season. The Jaguars defense also held three straight opponents to 17 points or fewer before the Houston shootout. Meanwhile, the Colts scored only 10 points last week, and now they replace an All-Pro guard in the middle of the season.
On the other side, Colts games have gone over in four of seven contests. Indianapolis turnovers could also create cheap points for Jacksonville. A defensive score or two short fields would push this total quickly. Lawrence has shown he can win a high-scoring game, as he did in London. Even so, a weakened Colts offense and a strong Jaguars defense point toward a game played in the low 40s.
The Pick: Under 46.5 (-110)
Final Thoughts and Bonus Angle
No moneyline or alternate angle offers clear value here. Jacksonville at -470 carries an implied probability of about 82.5 percent. That price leaves little room for a turnover swing or a late Colts rally. Indianapolis at +360 is live only if Jones protects the football, and his recent form does not support that bet. As a result, we are sticking to the side and the total.
The broader view is simple. Jacksonville is the better team, and it should win this game. The question is by how much. The opening number of 7.5 felt fair, while 10 asks the Jaguars to win comfortably against an opponent that rarely loses big. For more on how Indianapolis looked last week, see our Colts vs. Vikings Prediction and Best Bet for Sunday October 25, 2026.
Our picks for Colts vs. Jaguars:
- Colts +10 (-110)
- Under 46.5 (-110)
NFL Colts vs. Jaguars FAQ: Sunday November 1, 2026
What time does the Colts vs. Jaguars game start?
The Colts vs. Jaguars game kicks off at 1:00 PM ET on Sunday, November 1, 2026. It is part of the early Sunday afternoon window in Week 8 of the NFL season, with Jacksonville hosting its AFC South rival at home.
What channel is the Colts vs. Jaguars game on?
The Colts vs. Jaguars game airs on CBS. Kickoff is set for 1:00 PM ET on Sunday, November 1, 2026, so viewers should check their local CBS affiliate, since Sunday afternoon CBS games are distributed regionally across the country.
Where are the Colts and Jaguars playing?
The Colts and Jaguars play at EverBank Stadium in Jacksonville, Florida. The Jaguars are the home team for this Week 8 AFC South matchup, which is their first game back after a bye week that followed their loss to Houston in London.
Who won the last meeting between the Colts and Jaguars?
The Jaguars won the last meeting between the two teams in late December 2025. Jacksonville beat Indianapolis twice in a three-week span that month, sweeping the season series. The Colts have not won a game in Jacksonville since 2014.
What is the Colts’ record this season?
The Colts are 2-5 entering Week 8. They have lost three straight games, most recently falling 16-10 at Minnesota. Jacksonville, by contrast, is 4-2 and sits in first place in the AFC South heading into Sunday’s divisional matchup.