The Los Angeles Rams open SoFi Stadium for the 2026 season on Monday Night Football, and they do it as a full touchdown favorite over the New York Giants. The spread sits at Rams -7, the same number it opened at, while the Giants arrive at 1-0 after an impressive debut under John Harbaugh. Los Angeles, meanwhile, is 0-1 after a 27-7 loss to the 49ers in Australia. Below, we break down the spread, the juice movement, the public splits, and the injury news shaping both sides.
Last Updated: Monday, September 21, 2026
New York Giants vs. Los Angeles Rams — Time & How to Watch
| Where | SoFi Stadium, Inglewood, CA |
| When | Monday, September 21 – 8:15 PM ET |
| TV | ESPN, ABC |
New York Giants vs. Los Angeles Rams Matchup Overview
The Giants could not have scripted a better start to the Harbaugh era. New York beat Dallas 28-20 on Sunday Night Football in Week 1, and second-year quarterback Jaxson Dart was sharp. He completed 23 of 29 passes for 230 yards and three touchdowns, and he added 54 yards on the ground. Tight end Isaiah Likely caught all eight of his targets for 78 yards and two scores. Cam Skattebo ran for 81 yards and a touchdown, and Malik Nabers had six catches for 69 yards in his first game back from a torn ACL.
The Rams’ opener went the other way. Los Angeles led the NFL in scoring last season, yet it managed just seven points against San Francisco in Melbourne. Reigning MVP Matthew Stafford posted a 61.2 passer rating with an interception, and the offense committed two turnovers. Sean McVay’s team now needs a response in its home opener.
Injuries are a major part of this handicap. The Rams will be without Myles Garrett, who is headed for knee surgery and injured reserve after arriving in an offseason trade from Cleveland. Puka Nacua is listed as questionable with a hip issue after missing Friday and Saturday practice, and ESPN’s Adam Schefter reported Sunday that he is trending the wrong way. Safety Kamren Kinchens is out, and receiver Jordan Whittington is doubtful. On the Giants’ side, cornerback Paulson Adebo is on injured reserve with a knee injury. Fellow corner Deonte Banks (calf) and linebacker Micah McFadden (neck) are both listed as questionable.
History leans toward Los Angeles, which has won four straight in this series. The Giants’ last win came in 2016, long before Dart and Harbaugh arrived.
New York Giants vs. Los Angeles Rams Odds
| Spread | Moneyline | Total | |
|---|---|---|---|
| Giants | +7 (-120) | +265 | O 47.5 (-115) |
| Rams | -7 (+100) | -330 | U 47.5 (-105) |
Odds accurate as of Monday, September 21, 2026 via TheSpread.com. Odds change, get the latest NFL Odds – Futures – Props
New York Giants vs. Los Angeles Rams — Who Is the Public Betting?
| Giants | 57% | 43% | Rams |
See the latest NFL Public Betting Splits and make smarter wagers!
NFL Betting Angle for New York Giants vs. Los Angeles Rams
The spread number itself has not moved. Los Angeles opened at -7 with standard -110 juice on both sides. However, the price has shifted. The Giants +7 now costs -120, while the Rams -7 is priced at even money. Books are now charging more to take the touchdown with New York, which usually signals money on the underdog and a market leaning toward 6.5. The total has also ticked down half a point, from 48 to 47.5, with the Over now carrying the heavier -115 price.
The public splits match that movement. Bettors have 57% of spread tickets on the Giants, although 86% of moneyline tickets are on the Rams to win outright. In other words, many bettors expect Los Angeles to win but doubt it wins by more than a touchdown.
The case for the Giants plus the points is simple. Dart was efficient in Week 1, the offense sustained long drives, and the Rams’ pass rush takes a hit without Garrett. If Nacua sits, Stafford also loses his top target from a week when the passing game already sputtered.
The case for the Rams is just as real. One bad week in Australia does not erase last season’s league-best scoring offense or a reigning MVP at quarterback. The Rams’ -330 moneyline implies roughly a 77% chance to win, so the market still rates them clearly better. Meanwhile, the Giants’ secondary is shorthanded, with Adebo out and Banks questionable. Stafford could find far more room to throw than he did against San Francisco.
Can Jaxson Dart Exploit a Rams Defense Without Myles Garrett?
The Garrett trade was the Rams’ headline move of the offseason. Los Angeles landed the star pass rusher from Cleveland in a blockbuster deal. His debut, however, showed the knee was already a problem. Garrett logged five quarterback pressures against the 49ers but finished without a sack or a tackle. Now he will undergo knee surgery and land on injured reserve, which sidelines him for at least four games.
That matters because Dart hurt Dallas both as a passer and as a runner. Less edge pressure gives a mobile quarterback more time to extend plays. It also lets the Giants lean on Skattebo and keep the ball out of Stafford’s hands. Likely and Nabers give Dart two reliable targets, and New York’s ball-control approach worked well in the opener.
Still, that is one game of evidence, and it came at home. McVay now has film on Dart. For more NFC context, see our Seahawks vs. Cardinals prediction and Commanders vs. Cowboys prediction from Week 2. If Los Angeles can pressure Dart with its remaining rushers, the seven-point spread becomes much easier to cover.
NFL Giants vs. Rams FAQ: Monday September 21, 2026
What time does the Giants vs. Rams game start?
The Giants vs. Rams game kicks off at 8:15 PM ET (5:15 PM PT) on Monday, September 21, 2026. It is the Week 2 edition of Monday Night Football and serves as the Rams’ 2026 home opener. The game airs nationally on ESPN and ABC.
What channel is the Giants vs. Rams game on?
The Giants vs. Rams game airs nationally on ESPN and ABC as part of Monday Night Football. Kickoff from SoFi Stadium in Inglewood, California, is set for 8:15 PM ET, with the Rams hosting their first home game of the 2026 season.
Where are the Giants and Rams playing?
The Giants and Rams play at SoFi Stadium in Inglewood, California. It is the Rams’ 2026 home opener after they began the season against the 49ers in Melbourne, Australia. The Giants, meanwhile, are coming off a home win over Dallas in East Rutherford, New Jersey.
Who won the last meeting between the Giants and Rams?
The Rams won the last meeting 26-25 at MetLife Stadium in Week 17 of the 2023 season. Matthew Stafford threw for 317 yards and a touchdown, while Kyren Williams ran for 87 yards and three scores. That victory extended the Rams’ winning streak in the series to four games.
What are the Giants’ and Rams’ records this season?
The Giants are 1-0 after beating the Cowboys 28-20 in Week 1, while the Rams are 0-1 after a 27-7 loss to the 49ers. New York’s win came in John Harbaugh’s debut as head coach. The Rams’ loss came in Melbourne, Australia, where they scored just seven points.