CFB Week 5 Injury Report & Betting Impact

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Last Updated on September 26, 2025 10:08 am by Michael Cash

CFB Week 5 injury report & betting impact โ€” verified player statuses for the weeknight slate and every AP Top-25 Saturday matchup, with how those injuries correlate to opening vs. current lines. For live context, open the CFB public betting trends and browse the College Football hub.

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CFB Week 5 Injury Report โ€” Opening vs. Current Line Reads

  • Florida State at Virginia (Fri 7:00 ET) โ€” Open: FSU โˆ’7, 58.5 โ€ข Now: FSU ~โˆ’7, 60.5 (total ticked up after clean report).
  • TCU at Arizona State (Fri 9:00 ET) โ€” Open: ASU โˆ’3, 54.5 โ€ข Now: ASU ~โˆ’3, 54.5 (attrition priced in early).
  • Alabama at Georgia (Sat 7:30 ET) โ€” Open: UGA โˆ’3, 53.5 โ€ข Now: UGA ~โˆ’3, 53.5 (OL injury offsets Bama returns).
  • Oregon at Penn State (Sat 7:30 ET) โ€” Open: PSU โˆ’6.5, 52.5 โ€ข Now: PSU ~โˆ’3.5, 52.5 (steam toward Ducks).
  • LSU at Ole Miss (Sat 3:30 ET) โ€” Open: MISS โˆ’1.5, 56.0 โ€ข Now: MISS ~โˆ’1.5, 56.5 (offensive health lifts total).
  • Ohio State at Washington (Sat 3:30 ET) โ€” Open: OSU โˆ’10, 52.5 โ€ข Now: OSU ~โˆ’8.5, 51.5 (Huskies money despite LB loss).
  • USC at Illinois (Sat 12:00 ET) โ€” Open: USC โˆ’6.5, 59.5 โ€ข Now: USC ~โˆ’7, 60.5 (Illini secondary upgrades slowed Trojans steam).
  • Notre Dame at Arkansas (Sat 12:00 ET) โ€” Open: ND โˆ’6, 64.5 โ€ข Now: ND ~โˆ’4.5, 63.5 (market fade not injury-driven).
  • Georgia Tech at Wake Forest (Sat 12:00 ET) โ€” Open: GT โˆ’16.5, 53.5 โ€ข Now: GT ~โˆ’16.5, 53.5 (flat despite GT absences).
  • Indiana at Iowa (Sat 3:30 ET) โ€” Open: IOWA โˆ’7.5, 46.5 โ€ข Now: IOWA ~โˆ’7.5, 46.5 (awaiting B1G report).
  • BYU at Colorado (Sat 10:15 ET) โ€” Open: BYU โˆ’6.5, 49.5 โ€ข Now: BYU ~โˆ’7, 49.5 (BYU upgrades, CU DB room thin).
  • Arizona at Iowa State (Sat 7:00 ET) โ€” Open: ISU โˆ’6.5, 48.5 โ€ข Now: ISU ~โˆ’6.5, 48.5 (kicker issue affects totals more).
  • UMass at Missouri (Sat 7:30 ET) โ€” Open: MIZZ โˆ’44.5, 56 โ€ข Now: MIZZ ~โˆ’44.5, 56.5 (injuries not dictating price).

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College Football Week 5 Injuries โ€” Betting Impact

CFB Week 5 Friday Injury Notes

  • Florida State at Virginia โ€” FSU starters cleared, while UVA posted no new outs. Therefore the spread held โˆ’7 and totals drifted higher.
  • TCU at Arizona State โ€” ASU listed DB Xavion Alford, DE Albert Smith III, and WR Jalen Moss among six absences. Meanwhile TCU traveled healthy. As a result, the market froze at โˆ’3 with totals unchanged.

SEC Injury Impact

  • Alabama at Georgia โ€” RB Jam Miller and DT Tim Keenan III probable for Bama. Conversely UGA lost RT Earnest Greene III. Consequently, the line stuck near โˆ’3 with toggles 2.5โ€“3.5.
  • LSU at Ole Miss โ€” LSUโ€™s DE Bryce Reliford out for the year. Ole Miss posted no new absences. Therefore, the line stayed โˆ’1.5 and the total ticked upward.

Big Ten & Independent Injury Impact

  • Oregon at Penn State โ€” RB Noah Whittington upgraded, WR Evan Stewart still out. PSU remained clean. Thus, early Oregon buy drove โˆ’6.5 โ†’ โˆ’3.5.
  • Notre Dame at Arkansas โ€” Irish clean sheet, Arkansas status quo. Yet the line slipped to โˆ’4.5 on market drift, not health.
  • Indiana at Iowa โ€” B1G availability not yet posted. Consequently, the line froze at โˆ’7.5 until Saturday.
  • USC at Illinois โ€” USC CB Prophet Brown remains out. Illinois DB unit healthier. Hence, spread moved from โˆ’6.5 to โˆ’7 with modest total rise.

PAC-12 & Other Top-25 Impact

  • Ohio State at Washington โ€” UW LB Taariq Al-Uqdah sidelined. However, money poured on Huskies narrowing OSU โˆ’10 โ†’ โˆ’8.5.
  • Georgia Tech at Wake Forest โ€” GT missing DB Savion Riley, RB Chad Alexander, OL Tana Alo-Tupuola, TE Brett Seither. Still, line held double digits.
  • BYU at Colorado โ€” BYUโ€™s DE Kini Fonohema and RB Logan Payne upgraded. Conversely CU secondary remains depleted. Consequently, BYU drifted to โˆ’7.
  • Arizona at Iowa State โ€” ISU kicker out, Arizona no issues. Therefore line stayed โˆ’6.5 though total sensitivity increased.
  • UMass at Missouri โ€” Mizzou and UMass posted no new injuries. As expected, chalk held at โˆ’44.5.

CFB Week 5 Injury Report โ€” Kickoff Weather Windows

  • Oregon at Penn State โ€” mid-60s, light wind โ†’ totals unaffected.
  • Georgia Tech at Wake โ€” elevated rain chance; watch radar before kickoff.

CFB Week 5 Injury Report โ€” Market Reads & Buy/Sell Notes

  • Bama-UGA: OL loss vs. RB/DT return balanced โ†’ spread glued near โˆ’3.
  • Oregon-PSU: skill upgrades plus market steam explain 6.5โ†’3.5.
  • BYU-CU: BYU upgrades vs. CU thin DB room explain nudge to โˆ’7.
  • USC-ILL: Illini healthier DBs slowed Trojans steam beyond โˆ’7.

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