A Pac-12 (now Big Ten) heavyweight meets a scrambling Big 12 challenger as Oregon hosts Oklahoma State on Saturday, September 6, 2025. This Oregon vs Oklahoma State college football preview delivers the latest betting lines, public snapshot, and must-watch storylines heading into a game offering heavy atmosphere and mismatch intrigue. With Oregon riding momentum at Autzen and OSU grappling with quarterback injuries, overs may be tempting, but the Ducks’ depth could make this one a blowout.
Oregon vs. Oklahoma State Date/Time, Location & TV
- Date & Time: Saturday, September 6, 2025 – Kickoff 3:30 p.m. ET / 12:30 p.m. PT
- Location: Autzen Stadium, Eugene, OR
- TV/Streaming: CBS (also on Paramount+)
▸ It’s OSU’s first game ever at Oregon—a true statement stage.
Betting Odds (via Bovada)
- Point Spread: Oklahoma State +28.5 | Oregon –28.5
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Click here - Moneyline: Oklahoma State +2000 | Oregon –7000
- Total (Over/Under): 57.5 — Over (–110), Under (–110)
Public Betting Snapshot
A whopping 70%+ of public spread bets are on Oregon –28.5, showing confidence in a dominant home performance. Totals action also leans Over 57.5, as fans expect fireworks from a playoff-ready Ducks squad.
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College Football Public Betting Chart
News, Notes & Storylines
- Oregon enters as a national Top 10 favorite after a dominant Week 1. QB Dante Moore is electric, and the Ducks flexed all three phases—special teams, defense, and offense—in a clinic.
- Oklahoma State rolls in injury-riddled, starting backup QB Zane Flores after Hauss Hejny’s broken foot. Depth (or lack thereof) is being tested early for the Cowboys.
- The matchup includes off-field spice: coach Mike Gundy recently criticized Oregon’s NIL advantages, setting a fiery backdrop for this week’s atmosphere.
Oregon vs. Oklahoma State Trends
- ATS (Against The Spread): Ducks have been dominant—covering by wide margins in recent home games.
- O/U (Totals): The Over has hit in many of Oregon’s non-conference opening games.
- Public Betting: Heavy lean toward Oregon and Over.
- Line Movement: Opened near –28, now firmly –28.5, fueled by sharp and public money.
Previous Meetings
- 2008 Holiday Bowl: Oregon 42, Oklahoma State 31
- This will be their first regular-season meeting ever.
Final Thoughts
This one looks like a mismatch on paper—Oregon’s explosive offense and OSU’s depleted QBs point toward a Ducks blowout. Backing Oregon to cover is logical, but for value players, the Over 57.5 offers upside if the pace stays high.
Bet Considerations:
- Spread: Oregon –28.5 should control the board.
- Total: Lean toward Over—Oregon has a history of quick starts, even in lopsided games.
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Oregon vs. Oklahoma State Snapshot
| Detail | Info |
|---|---|
| Date & Time | Saturday, Sept 6, 2025 – 3:30 p.m. ET |
| Location | Autzen Stadium, Eugene, OR |
| TV | CBS / Paramount+ |
| Spread | Oklahoma State +28.5 / Oregon –28.5 |
| Moneyline | OSU +2000 / Oregon –7000 |
| Total (O/U) | 57.5 (O –110 / U –110) |
| Public Betting | Over 70% on Oregon to cover |
| Series History | Oregon won 2008 Holiday Bowl |
| Trends | Ducks dominate early, Over favored |