Last Updated on September 3, 2025 9:13 am by Michael Cash
Friday night football arrives in Week 1 with a marquee AFC West battle as the Kansas City Chiefs take on the Los Angeles Chargers on September 5, 2025. This Chiefs vs Chargers NFL preview dives into the latest betting odds, public betting snapshot, key injuries, and rivalry context as Patrick Mahomes and Justin Herbert square off in an early-season primetime clash.
Chiefs vs Chargers Date/Time, Location & TV
- Date & Time: Friday, September 5, 2025 — 8:15 p.m. ET
- Location: SoFi Stadium, Inglewood, California
- TV/Streaming: Amazon Prime Video
Betting Odds (via Bovada)
- Point Spread: Chiefs –3.0 | Chargers +3.0
- Moneyline: Chiefs –160 | Chargers +135
- Total (Over/Under): 49.5 — Over (–110), Under (–110)
Public Betting Snapshot
Early betting action shows a slight majority backing the Chiefs against the spread, while moneyline tickets are more evenly split with some value seen on the Chargers as home underdogs. Totals betting trends lean toward the Over, consistent with past high-scoring matchups in this rivalry.
👉 Track updated splits here: NFL Public Betting Chart
News, Notes & Storylines
- Mahomes vs. Herbert: Two of the league’s premier quarterbacks headline another chapter in this AFC West rivalry, with past meetings often coming down to late-game heroics.
- Chargers Reloaded: Los Angeles enters 2025 under new leadership, looking to rebound from last season’s inconsistencies and re-establish itself as a playoff contender.
- Chiefs’ Quest for More: Kansas City continues its dynasty run, opening the season with strong Super Bowl odds and a revamped offensive line to protect Mahomes.
- Prime-Time Drama: This is the only Friday night game of Week 1, giving it standalone spotlight across the NFL landscape.
Injuries
- Kansas City Chiefs: WR Marquise Brown (questionable, hamstring); DE George Karlaftis (probable).
- Los Angeles Chargers: OT Rashawn Slater (questionable, ankle); CB Asante Samuel Jr. (questionable, concussion protocol).
Chiefs vs Chargers Trends
- ATS (Against The Spread): Chiefs have covered 4 of their last 6 games vs. Chargers.
- O/U (Totals): The Over has cashed in 5 of the last 7 meetings between these teams.
- Line Movement: Opened Chiefs –2.5, moved to –3 with steady support on Kansas City.
- Public Betting: Bettors leaning toward Kansas City spread and Over on the total.
Previous Meetings (Last 3 Matchups)
- 2024: Chiefs 27–20 (Arrowhead)
- 2024: Chiefs 34–31 (SoFi, OT thriller)
- 2023: Chiefs 30–24
Final Thoughts
Expect fireworks under the lights as Mahomes and Herbert renew their rivalry. Kansas City’s stability and postseason pedigree make them the deserved favorite, but the Chargers’ home-field energy and improved roster could turn this into another classic.
Bet Considerations:
- Spread: Lean Chiefs –3.0 with Mahomes’ proven ability in tight divisional games.
- Total: Strong lean to the Over 49.5 given both offenses’ explosiveness and recent scoring history.
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Chiefs vs Chargers Snapshot
| Detail | Info |
|---|---|
| Date & Time | Friday, Sept 5, 2025 — 8:15 p.m. ET |
| Location | SoFi Stadium, Inglewood, CA |
| TV | Amazon Prime Video |
| Spread | Chiefs –3.0 / Chargers +3.0 |
| Moneyline | Chiefs –160 / Chargers +135 |
| Total (O/U) | 49.5 points |
| Public Betting | Lean toward Chiefs and Over |
| Series History | Chiefs won both 2024 meetings |
| Trends | Chiefs ATS edge; Over trending |
| Injuries | KC: Brown Q. LAC: Slater Q, Samuel Jr. Q |