Friday CBB Best Bets March 6: Can Seton Hall upset St. John's?

Friday features a moderate college basketball slate with several mid-major teams and a handful of high-major schools taking the floor on the 6th day of March 2026. Will St. John’s beat Seton Hall by 5 points or more at the Prudential Center in Newark, NJ? Can Miami Ohio win and cover on the road in Athens, Ohio, to finish the regular season undefeated? Read on for our Friday CBB Best Bets March 6 article.

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CBB Best Bet: Seton Hall +4.5 over St. John’s

I like the Pirates here. Seton Hall is well-positioned to cover the 4.5-point spread as home underdogs against St. John’s on Friday night. The Pirates excel in this spot, boasting a dominant 9-1 ATS record as underdogs this season.

They maintain a steady 10-9 ATS mark following a win and possess a stellar 12-5 ATS record when playing an opponent on equal rest this year. Riding a 5-2 ATS streak over their last seven games overall, the Pirates also historically control this rivalry, sitting at 7-3 ATS in their last 10 against the Red Storm. Expect a gritty, down-to-the-wire battle.

Final score projection: SETON HALL PIRATES 73, ST. JOHN’S RED STORM 71.

CBB Best Bet: Miami Ohio -5.5 over Ohio

I’m taking the RedHawks in this one. Miami Ohio is set to cover the 5.5-point spread against Ohio on Friday night, fueled by their historic 30-0 straight-up record as the only remaining undefeated team in college basketball this season. Miami Ohio also has the third-best ATS mark, 19-8, in the country this season. They’ve excelled in several different scenarios this year.

The RedHawks are a bettor’s dream, boasting an elite 10-3 ATS mark on the road and a reliable 15-8 ATS record as favorites in 2025-26. Their momentum has been strong, evidenced by an 18-8 ATS record following a win and a steely 11-6 ATS mark in conference play this season. Look for Miami to comfortably win this in-state rivalry contest.

Final score projection: MIAMI OHIO REDHAWKS 84, OHIO BOBCATS 74.