Wednesday’s MLB slate features 15 matchups on May 20, 2026, with start times spanning from 1:05 PM ET to 9:38 PM ET.
I like a pair of teams playing in the evening on Wednesday. Both teams are small favorites facing off against divisional foes.
Can 25-year-old Cardinals righty Michael McGreevy pitch well enough to earn his fourth win of the season on Wednesday? Will Athletics starter Aaron Civale improve his 2026 record to 6-1 in a road showdown with the Angels?
I'll make picks for both games below. Read on for our Wednesday MLB Predictions May 20 article.
MLB Prediction Game 1
PIRATES VS CARDINALS DATE, TIME & HOW TO WATCH | |
|---|---|
| Where | BUSCH STADIUM, ST. LOUIS, MO |
| When | WEDNESDAY, MAY 20, 2026, 7:45 PM ET |
| TV | MLB.TV |
PIRATES VS CARDINALS ODDS | |||
|---|---|---|---|
| Run Line | Moneyline | Total | |
| PIRATES | 1.5 (-210) | +100 | U 8.0 (-120) |
| CARDINALS | -1.5 (+175) | -120 | O 8.0 (+100) |
Odds change, get the latest MLB Odds - Futures - Props
PIRATES VS CARDINALS WHO IS THE PUBLIC BETTING? | |||
|---|---|---|---|
| PIRATES | 35% | 65% | CARDINALS |
See the latest MLB Public Betting Splits and make smarter wagers!
Pittsburgh Pirates at St. Louis Cardinals May 20 MLB Prediction
The St. Louis Cardinals are in a good spot to win outright as money-line home favorites against the Pittsburgh Pirates on Wednesday night.
St. Louis has been highly reliable in this spot, boasting a 5-1 straight-up record as a favorite and a dominant 6-1 straight-up mark in division games this season. They also protect their home turf well, sitting at 13-11 straight up as the home team, and maintain momentum effectively with a 16-11 straight up record after a win in 2026.
Furthermore, the Cardinals have owned this specific matchup recently, going a flawless 6-0 straight up in their last 6 games against the Pirates. These situational trends heavily point toward a St. Louis victory.
Pick: St. Louis Cardinals -120
MLB Prediction Game 2
ATHLETICS VS ANGELS DATE, TIME & HOW TO WATCH | |
|---|---|
| Where | ANGEL STADIUM, ANAHEIM, CA |
| When | WEDNESDAY, MAY 20, 2026, 9:38 PM ET |
| TV | MLB.TV |
ATHLETICS VS ANGELS ODDS | |||
|---|---|---|---|
| Run Line | Moneyline | Total | |
| ATHLETICS | -1.5 (+130) | -123 | U 9.5 (-115) |
| ANGELS | 1.5 (-150) | +103 | O 9.5 (-105) |
ATHLETICS VS ANGELS WHO IS THE PUBLIC BETTING? | |||
|---|---|---|---|
| ATHLETICS | 66% | 34% | ANGELS |
Athletics at Los Angeles Angles May 20 MLB Prediction
The Athletics are perfectly positioned to win outright as money-line road favorites against the Los Angeles Angels on Wednesday night.
The A's have thrived in spots like these, boasting a 17-16 straight-up record in American League matchups and a strong 9-6 straight-up mark in division play this season. They also perform well away from home, sitting at 14-12 straight up as the road team, and handle quick turnarounds efficiently with a 22-19 straight up record when playing on no rest in 2026.
Additionally, recent history favors the Athletics, who have gone 5-3 straight up in their last 8 games against the Angels. For all of these reasons, I'm backing the Athletics on the road against the Angels on Wednesday.
Pick: Athletics -123
Today's MLB Predictions
- St. Louis Cardinals -120
- Athletics -123