Two clubs clinging to faint wild-card hopes meet at Busch Stadium on Tuesday night as the Baltimore Orioles open a three-game interleague set against the St. Louis Cardinals. Both teams arrive cold. Baltimore has dropped five of its last seven, while St. Louis lost three straight and was swept in Philadelphia, capped by a walk-off defeat after leading 4-0. The Cardinals sit as home favorites at -133. Our read leans toward the road side and a quieter scoreboard, and the market may be hinting the same way.
Last Updated: Tuesday, August 25, 2026
Baltimore Orioles vs. St. Louis Cardinals — Time & How to Watch
| Where | Busch Stadium, St. Louis, MO |
| When | August 25, 2026 — 7:45 PM ET |
| TV | MASN, Cardinals.TV & MLB.TV |
Baltimore Orioles vs. St. Louis Cardinals Betting Preview
The pitching sets the tone here, and it starts with a known quantity for Baltimore. Right-hander Chris Bassitt is scheduled to take the ball with a 4-4 record and a 5.08 ERA. The season line is unremarkable, but his recent work has been steadier. He owns a 4.09 ERA with nine strikeouts and four walks across two starts since returning from the injured list following back surgery. The caveat is workload. He is still building back up, so his pitch count and length are worth watching.
St. Louis, in contrast, had not settled its rotation for the series. Injuries and an innings limit on a young arm left manager Oli Marmol weighing his options, with lefty Matthew Liberatore (5-11, 5.04 ERA) reported as the likeliest starter but not confirmed. A team that cannot name its starter two days out is rarely operating from strength, and Liberatore’s ERA sits in the same shaky range as Bassitt’s.
The bats are the bigger concern for the home side. Shortstop Masyn Winn has missed four straight games with a left thumb injury, outfielder Everson Pereira landed on the injured list, and rookie Joshua Baez has scuffled through a 2-for-32 stretch. A depleted, slumping lineup in a pitcher-friendly park is a meaningful backdrop for both the side and the total. Baltimore’s offense has been quiet too, so neither team enters swinging hot.
Baltimore Orioles vs. St. Louis Cardinals Odds
| Run Line | Moneyline | Total | |
|---|---|---|---|
| Orioles | +1.5 (-195) | +111 | U 8.5 (+100) |
| Cardinals | -1.5 (+165) | -133 | O 8.5 (-120) |
Odds accurate as of Tuesday, August 25, 2026 via TheSpread.com. Odds change, get the latest MLB Odds – Futures – Props
Baltimore Orioles vs. St. Louis Cardinals — Who Is the Public Betting?
| Orioles | 45% | 55% | Cardinals |
See the latest MLB Public Betting Splits and make smarter wagers!
Orioles vs. Cardinals Prediction — Public Wrong About Redbirds?
Start with the market, because it is doing something quietly interesting. Roughly 70% of moneyline bets are on the Cardinals at -133, yet the price has not budged from where it opened. When heavy public money piles onto one side and the number refuses to move toward it, that frozen line often points the other way, and here it points to Baltimore. The run-line split is far more balanced at 55-45, which reinforces that the lopsided figure is a moneyline story, not a broad market verdict.
The baseball backs the lean. Bassitt is the more settled arm in this matchup, a veteran throwing well over his last two outings against a St. Louis club that could not confirm its own starter and is missing two regulars in Winn and Pereira. At +111, the Orioles carry an implied probability of about 47%, a fair price for a road underdog whose opponent is banged up and short on offense. This projects as a tight, low-scoring game, which is exactly the profile where the moneyline is a cleaner play than laying the run line.
The case against is real. Bassitt’s post-surgery workload could force an early exit and hand the game to Baltimore’s bullpen, and home favorites win these coin-flip games often enough that -133 is not a mistake. Still, value lives where the price underrates a side, and the frozen line suggests this one does.
The Pick: Baltimore Orioles Moneyline (+111)
Orioles vs. Cardinals Prediction — Thin Lineup = Quiet Night?
The total tells a similar story from a different angle. Busch Stadium has long played as one of the more pitcher-friendly parks in the National League, suppressing home runs and holding down run expectation. Layer that environment over two lineups that are not swinging well, a St. Louis order missing Winn and Pereira, and a posted number of just 8.5, and the under becomes the more comfortable side. Getting it at +100 is plus-money value on a read the park itself supports.
The counter is that neither starter is a shutdown arm. Two pitchers carrying ERAs above 5.00 can put runners on, and if Bassitt exits early the bullpens could turn a quiet game loud. That is the honest risk, and it is why this is a lean rather than a hammer. It also rests on the same soft Cardinals offense that anchors the side play, so treat the two picks as connected reads rather than independent ones.
The Pick: Under 8.5 (+100)
Final Thoughts and Bonus Angle
The swing factor is Bassitt’s pitch count. If he can turn the order over three times and hand a lead to the back of Baltimore’s bullpen, both picks are in good shape. If St. Louis finally confirms and runs out a fresh arm, or if Winn returns to steady the lineup, the home side becomes tougher to fade. Watch the lineup card and the first-pitch confirmation before betting. For more plays across the slate, see our latest MLB best bets.
To recap the card for Orioles at Cardinals: the lean is Baltimore Orioles Moneyline (+111) as the featured play, with Under 8.5 (+100) as the supporting angle. Both rest on a cold St. Louis offense and a pitcher-friendly park, so treat them as connected reads.
MLB Orioles vs. Cardinals FAQ: Tuesday August 25, 2026
What time does the Orioles vs. Cardinals game start?
First pitch is set for 7:45 PM ET on Tuesday, August 25, 2026, at Busch Stadium in St. Louis. That is 6:45 PM local time in the Central zone. The game opens a three-game interleague series and the first leg of Baltimore’s three-city road trip.
What channel is the Orioles vs. Cardinals game on?
The game airs locally on MASN in the Baltimore market and on Cardinals.TV in the St. Louis market. Out-of-market fans can stream it through MLB.TV. Cardinals.TV became the club’s local broadcast home beginning with the 2026 season, replacing the previous regional sports network.
Where are the Orioles and Cardinals playing today?
The Orioles and Cardinals play at Busch Stadium in St. Louis, Missouri, on Tuesday, August 25, 2026. It is the opener of a three-game interleague series and the first stop on Baltimore’s road trip. Busch Stadium has long graded as a pitcher-friendly ballpark.
Who is pitching for Baltimore tonight?
Right-hander Chris Bassitt is scheduled to start for the Orioles, carrying a 4-4 record and a 5.08 ERA on the season. He has pitched better lately, posting a 4.09 ERA with nine strikeouts across two starts since returning from the injured list.