Friday’s MLB slate features 15 matchups on May 15, 2026, with start times spanning from 6:40 PM ET to 9:40 PM ET.
I like a pair of teams playing in the evening on Friday. Both teams are underdogs playing in interleague contests and using starting pitchers with ERAs below 3.10.
Can 33-year-old Mets righty Clay Holmes pitch well enough to earn his fifth win of the season on Friday? Will Padres starter Randy Vasquez improve his 2026 record to 5-1 in a road matchup with the Mariners?
I'll make picks for both games below. Read on for our Friday MLB Predictions May 15 article.
MLB Prediction Game 1
YANKEES VS METS DATE, TIME & HOW TO WATCH | |
|---|---|
| Where | CITI FIELD, QUEENS, NY |
| When | FRIDAY, MAY 15, 2026, 7:10 PM ET |
| TV | APPLE TV |
YANKEES VS METS ODDS | |||
|---|---|---|---|
| Run Line | Moneyline | Total | |
| YANKEES | -1.5 (+114) | -153 | U 7.5 (-132) |
| METS | 1.5 (-142) | +128 | O 7.5 (+105) |
Odds change, get the latest MLB Odds - Futures - Props
YANKEES VS METS WHO IS THE PUBLIC BETTING? | |||
|---|---|---|---|
| YANKEES | 81% | 19% | METS |
See the latest MLB Public Betting Splits and make smarter wagers!
New York Yankees at New York Mets May 15 MLB Prediction
The New York Mets are perfectly positioned to pull off an upset and win outright as money line home underdogs against the New York Yankees on Friday night.
The Mets handle AL opponents well, going 7-5 straight up in interleague games, and they maintain their momentum with a solid 9-8 straight up mark after a win this season. Most compellingly, the Mets are a flawless 3-0 straight up as a home underdog this season.
New York's NL team is surging at the right time, sitting at 7-3 straight up in their last 10 games overall. The Mets also hold an identical 7-3 straight-up mark in their last 10 matchups against the Yankees. Expect the Mets to defend their home turf and deliver an outright underdog victory.
Pick: New York Mets +128
MLB Prediction Game 2
PADRES VS MARINERS DATE, TIME & HOW TO WATCH | |
|---|---|
| Where | T-MOBILE PARK, SEATTLE, WA |
| When | FRIDAY, MAY 15, 2026, 9:40 PM ET |
| TV | MLB.TV |
PADRES VS MARINERS ODDS | |||
|---|---|---|---|
| Run Line | Moneyline | Total | |
| PADRES | 1.5 (-183) | +119 | U 7.5 (-131) |
| MARINERS | -1.5 (+146) | -143 | O 7.5 (+109) |
PADRES VS MARINERS WHO IS THE PUBLIC BETTING? | |||
|---|---|---|---|
| PADRES | 27% | 73% | MARINERS |
San Diego Padres at Seattle Mariners May 15 MLB Prediction
The San Diego Padres are well-suited to win outright as money line road underdogs against the Seattle Mariners on Friday night.
San Diego thrives on quick turnarounds, boasting an impressive 22-13 straight-up record when playing on no rest this season. They consistently take care of business away from home, sitting at 11-7 straight up as the road team and 5-4 straight up as road underdogs in 2026. The Padres also excel when doubted, going 10-9 straight up as an underdog this season.
Most importantly, San Diego dominates this specific matchup, owning a decisive 4-1 straight-up mark in their last 5 games against the Mariners. Expect the Padres' stellar pitching and hitting to lead to an outright underdog triumph.
Pick: San Diego Padres +119
Today's MLB Predictions
- New York Mets +128
- San Diego Padres +119