Friday’s full MLB slate features 15 matchups on June 5, 2026, with start times spanning from 2:20 PM ET to 10:10 PM ET.
I like a pair of NL East teams playing out west on Friday. Both teams are sending starters to the mound with ERAs under 3.80.
Can 26-year-old Mets righty Christian Scott pitch well enough to earn his second win of the season on Friday? Will Nationals starter Foster Griffin improve his record to 7-2 in a road matchup with the Diamondbacks?
I'll make picks for both games below. Read on for our Friday MLB Predictions June 5 article.
MLB Prediction Game 1
METS VS PADRES DATE, TIME & HOW TO WATCH | |
|---|---|
| Where | PETCO PARK, SAN DIEGO, CA |
| When | FRIDAY, JUNE 5, 2026, 9:40 PM ET |
| TV | MLB.TV |
METS VS PADRES ODDS | |||
|---|---|---|---|
| Run Line | Moneyline | Total | |
| METS | 1.5 (-192) | +115 | O 7.5 (-125) |
| PADRES | -1.5 (+178) | -122 | U 7.5 (+105) |
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METS VS PADRES WHO IS THE PUBLIC BETTING? | |||
|---|---|---|---|
| METS | 31% | 69% | PADRES |
See the latest MLB Public Betting Splits and make smarter wagers!
New York Mets at San Diego Padres June 5 MLB Prediction
The New York Mets offer strong moneyline underdog value Friday night against the Padres, backed by recent momentum and key starting pitching metrics. Christian Scott brings a 2.97 ERA, 1.38 WHIP, and an elite 11.3 K/9 into Friday's contest. His stuff should play well against San Diego.
Beyond the mound, the Mets are hitting their stride as they are 5-2 straight up in their last 7 games overall and 6-3 straight up when playing on 1 day of rest this season. They also hold a reliable 14-12 straight-up record after a win in 2026.
Conversely, the Padres are fading quickly, stumbling to a dismal 3-11 straight up mark in their last 14 games overall. Take the Mets in this one.
Pick: New York Mets +115
MLB Prediction Game 2
NATIONALS VS DIAMONDBACKS DATE, TIME & HOW TO WATCH | |
|---|---|
| Where | CHASE FIELD, PHOENIX, AZ |
| When | FRIDAY, JUNE 5, 2026, 9:40 PM ET |
| TV | MLB.TV |
NATIONALS VS DIAMONDBACKS ODDS | |||
|---|---|---|---|
| Run Line | Moneyline | Total | |
| NATIONALS | 1.5 (-180) | +112 | O 9.5 (+100) |
| DIAMONDBACKS | -1.5 (+155) | -134 | U 9.5 (-120) |
NATIONALS VS DIAMONDBACKS WHO IS THE PUBLIC BETTING? | |||
|---|---|---|---|
| NATIONALS | 34% | 66% | DIAMONDBACKS |
Washington Nationals at Arizona Diamondbacks June 5 MLB Prediction
The Washington Nationals are well-positioned to win outright as money line road underdogs against the Diamondbacks on Friday night.
Washington has thrived away from home all season, boasting an impressive 19-12 straight up record as the road team and an 18-12 mark as a road underdog in 2026. They’ve also handled non-division opponents well, going 22-18 straight up in those matchups.
Beyond situational trends, the Nationals hold a distinct head-to-head edge, winning 4 of their last 5 games against Arizona. With Foster Griffin taking the mound, Washington has even more reason for confidence; the team is a stellar 9-3 straight up in his 12 starts this season, positioning them perfectly for an upset road victory.
Pick: Washington Nationals +112
Today's MLB Predictions
- New York Mets +115
- Washington Nationals +112