Wednesday’s full MLB slate features 15 matchups on June 3, 2026, with start times spanning from 1:05 PM ET to 9:40 PM ET.
I like a pair money line underdogs on Wednesday. Both teams are sending starters to the hill with ERAs under 3.10.
Can 26-year-old Guardians righty Gavin Williams pitch well enough to earn his ninth win of the season on Wednesday? Will Astros starter Spencer Arrighetti improve his record to 8-1 in a home matchup with the Pirates?
I'll make picks for both games below. Read on for our Wednesday MLB Predictions June 3 article.
MLB Prediction Game 1
GUARDIANS VS YANKEES DATE, TIME & HOW TO WATCH | |
|---|---|
| Where | YANKEE STADIUM, BRONX, NY |
| When | WEDNESDAY, JUNE 3, 2026, 7:05 PM ET |
| TV | PRIME VIDEO |
GUARDIANS VS YANKEES ODDS | |||
|---|---|---|---|
| Run Line | Moneyline | Total | |
| GUARDIANS | 1.5 (-160) | +130 | O 7.5 (+100) |
| YANKEES | -1.5 (+135) | -155 | U 7.5 (-120) |
Odds change, get the latest MLB Odds - Futures - Props
GUARDIANS VS YANKEES WHO IS THE PUBLIC BETTING? | |||
|---|---|---|---|
| GUARDIANS | 20% | 80% | YANKEES |
See the latest MLB Public Betting Splits and make smarter wagers!
Cleveland Guardians at New York Yankees June 3 MLB Prediction
The Cleveland Guardians are primed to win outright as money line road underdogs against the New York Yankees on Wednesday night.
Cleveland is 18-13 straight up as the road team, 11-8 straight up as a road underdog this season, and 18-12 straight up as an underdog overall in 2026. Situational trends also favor Cleveland, who are 26-22 straight up in non-division games and 24-17 straight up in American League games this season.
Finally, the Guardians hold a distinct pitching advantage, going 9-3 straight up in starting pitcher Gavin Williams' 12 starts this season. His elite 3.07 ERA, 1.09 WHIP, and 10.4 K/9 metrics should help his team secure the road upset.
Pick: Cleveland Guardians +130
MLB Prediction Game 2
PIRATES VS ASTROS DATE, TIME & HOW TO WATCH | |
|---|---|
| Where | DAIKIN PARK, HOUSTON, TX |
| When | WEDNESDAY, JUNE 3, 2026, 8:10 PM ET |
| TV | MLB.TV |
PIRATES VS ASTROS ODDS | |||
|---|---|---|---|
| Run Line | Moneyline | Total | |
| PIRATES | -1.5 (+113) | -165 | O 7.5 (+105) |
| ASTROS | 1.5 (-122) | +139 | U 7.5 (-125) |
PIRATES VS ASTROS WHO IS THE PUBLIC BETTING? | |||
|---|---|---|---|
| PIRATES | 68% | 32% | ASTROS |
Pittsburgh Pirates at Houston Astros June 3 MLB Prediction
The Houston Astros are well-positioned to win outright as money line home underdogs against the Pittsburgh Pirates on Wednesday night.
Houston carries strong recent momentum, going 7-4 straight up in their last 11 games overall. The driving force behind this potential home upset, however, is their starting pitcher.
The Astros are an incredible 7-1 straight up in starting pitcher Spencer Arrighetti's 8 starts this season. His elite metrics (1.34 ERA, 1.13 WHIP, and .167 opponent batting average) demonstrate how sharp he has been in 2026.
Arrighetti's pitching should be the deciding factor in this contest and should provide the foundation to stifle the Pirates and secure the victory.
Pick: Houston Astros +139
Today's MLB Predictions
- Cleveland Guardians +130
- Houston Astros +139