Friday’s full MLB slate features 15 matchups on May 22, 2026, with start times spanning from 2:20 PM ET to 10:15 PM ET.
I like a pair of teams playing in the evening on Friday. Both teams are facing NL West opponents.
Can 24-year-old Brewers righty Logan Henderson pitch well enough to earn his second win of the season on Friday? Will White Sox starter Davis Martin keep rolling and improve his record to 7-1 in a road showdown with the Giants?
I'll make picks for both games below. Read on for our Friday MLB Predictions May 22 article.
MLB Prediction Game 1
DODGERS VS BREWERS DATE, TIME & HOW TO WATCH | |
|---|---|
| Where | AMERICAN FAMILY FIELD, MILWAUKEE, WI |
| When | FRIDAY, MAY 22, 2026, 7:40 PM ET |
| TV | MLB.TV |
DODGERS VS BREWERS ODDS | |||
|---|---|---|---|
| Run Line | Moneyline | Total | |
| DODGERS | -1.5 (+145) | -114 | U 8.5 (-115) |
| BREWERS | 1.5 (-170) | -106 | O 8.5 (-105) |
Odds change, get the latest MLB Odds - Futures - Props
DODGERS VS BREWERS WHO IS THE PUBLIC BETTING? | |||
|---|---|---|---|
| DODGERS | 75% | 25% | BREWERS |
See the latest MLB Public Betting Splits and make smarter wagers!
Los Angeles Dodgers at Milwaukee Brewers May 22 MLB Prediction
The Milwaukee Brewers have a legit shot to win outright as home underdogs against the Los Angeles Dodgers on Friday night.
Milwaukee consistently thrives under these exact conditions. The Brewers boast an impressive 19-9 straight-up record following a victory and a strong 15-9 straight-up mark as the home team this year. They also naturally embrace this specific role, holding an 8-6 straight-up record as an underdog, while maintaining a solid 13-10 straight-up mark in National League games this season.
The Brewers carry massive momentum into this contest, sitting at 11-2 straight up in their last 13 games overall. Riding a modest 3-game winning streak, Milwaukee possesses the firepower, talent, and confidence to upset Los Angeles.
Pick: Milwaukee Brewers -106
MLB Prediction Game 2
WHITE SOX VS GIANTS DATE, TIME & HOW TO WATCH | |
|---|---|
| Where | ORACLE PARK, SAN FRANCISCO, CA |
| When | FRIDAY, MAY 22, 2026, 10:15 PM ET |
| TV | MLB.TV |
WHITE SOX VS GIANTS ODDS | |||
|---|---|---|---|
| Run Line | Moneyline | Total | |
| WHITE SOX | -1.5 (+152) | -115 | U 7.5 (+114) |
| GIANTS | 1.5 (-192) | -105 | O 7.5 (-137) |
WHITE SOX VS GIANTS WHO IS THE PUBLIC BETTING? | |||
|---|---|---|---|
| WHITE SOX | 61% | 39% | GIANTS |
Chicago White Sox at San Francisco Giants May 22 MLB Prediction
The Chicago White Sox offer excellent value to win outright as money line road favorites against the San Francisco Giants on Friday night.
Chicago consistently bounces back, carrying a solid 12-11 straight-up record after a loss in 2026. They perform well when rested, holding a 4-3 straight-up mark when playing on one day of rest and a 25-24 straight-up record when playing opponents on equal rest this season.
The White Sox bring significant momentum into this matchup, sitting at 8-3 straight up in their last 11 games overall. Most importantly, Chicago dominates with Davis Martin on the mound, boasting an elite 8-1 straight-up record in his 9 starts this season. Take Davis Martin and the Chi Sox in this one.
Pick: Chicago White Sox -115
Today's MLB Predictions
- Milwaukee Brewers -106
- Chicago White Sox -115