NFL Week 9 4PM Best Bets – Picks & Predictions

NFL Week 9 4PM Best Bets – Picks & Predictions NFL Week 9 4PM Best Bets – Picks & Predictions

Last Updated on November 2, 2025 3:49 pm by Michael Cash

LAS VEGAS — NFL Week 9 4PM Best Bets zero in on three late-window matchups with actionable value: Jaguars–Raiders, Saints–Rams, and Chiefs–Bills. We call a clear pick for each game, explain the why, and note key buy points so you can make the best, more informed bets you can. Let’s get into our 4PM Best Bets for NFL Week 9!🔔 Follow updates: Twitter/X · Bluesky · Facebook

💸 Compare every live number before you bet: Shop current odds 🏈

NFL Week 9 4PM Best Bets — Picks & Predictions

Jaguars at Raiders — Pick: Under 44.5

Market: JAX −2.5 (−105) / LV +2.5 (−115) · Total 44.5 (−105/−115) now 44 (-110) 3:50PM . Jacksonville’s defense is built to rally-and-tackle, and Las Vegas plays slow with a low early-down pass rate. Therefore, sustained 10+ play drives and red-zone field goals are live outcomes. We prefer Under 44.5 down to 44. Buy back off if weather/injury news pops the number below 44 early.

Saints at Rams — Pick: Saints +14

Market: NO +14 (−110) / LAR −14 (−110) Now 14.5 Updated 3:50PM Total 44.0. Two touchdowns is a premium in the NFL. New Orleans’ defense can limit explosives and force the Rams to finish long series. Meanwhile, late-game variance favors a +14 cover (backdoor live). We’d avoid +13.5; if books offer −115 at +14, it’s still playable.

NFL Week 9 4PM Best Bets: Chiefs at Bills — Pick: Over 52.5

Market: KC −2 (−110) / BUF +2 (−110) · Total 52.5 (−110) now 53 (-105/-115) updated 3:50PM. Both offenses rank top-tier in early-down success and scripted efficiency. Because pace accelerates in close games, fourth-quarter possessions stretch, and coaching aggressiveness rises on fourth down, we like the Over 52.5. Buy up to 53; above 53.5, reduce stake.

How to play the late window like a pro

  • Key numbers & hooks: Protect 14 on Saints; protect 44/45 on JAX–LV totals; watch 53 on KC–BUF.
  • Public vs sharps: Track consensus, but follow price action. Use our NFL public betting chart to spot fades and timing windows.
  • Beat the close: Read our CLV guide and line-shopping primer. Keep the NFL hub open for injuries and weather updates.

🔎 Compare live odds & line movement: Check your best number

Responsible Gaming

Bet responsibly. If you or someone you know has a gambling problem and wants help, please visit our Responsible Gaming page or contact the National Council on Problem Gambling for confidential 24/7 support.

Affiliate Disclosure

Some links in this article are affiliate links. If you click them and make a purchase or deposit, we may earn a commission at no additional cost to you. For details, see our Affiliate Disclosure.