Last Updated on October 24, 2025 1:28 am by Alex Becker
The Minnesota Timberwolves head to L.A. to face the Lakers on Friday night at 10:00 PM ET. It’s NBA opening week on Prime Video. Can the Lakers cover the 2.5-point spread as home underdogs? Keep reading for our Timberwolves vs. Lakers betting prediction.
The Minnesota Timberwolves are 1-0 straight up in the regular season this year. They are 0-1 ATS this season.
The Los Angeles Lakers are 0-1 straight up in the regular season this year. They are 0-1 ATS this season.
Timberwolves vs. Lakers Matchup & Betting Odds
551 Minnesota Timberwolves (-2.5) at 552 Los Angeles Lakers (+2.5); o/u 225.5
10:00 p.m. ET, Friday, October 24, 2025
Crypto.com Arena, Los Angeles, CA
TV: Prime Video
Timberwolves vs. Lakers Public Betting Information
Our NBA Public Betting Information page indicates that 84% of public bettors are currently backing the Timberwolves when it comes to the spread. This information is subject to change throughout the day, however, so be sure to check the link so you’re receiving the most up-to-date public betting data.
Minnesota Timberwolves Daily Fantasy Spin
Timberwolves guard Anthony Edwards led his team in scoring in their 118-114 win over the Trail Blazers on Wednesday night. In that game, the 3-time All-Star recorded 41 points, 7 rebounds, an assist, and 8 made free throws. Edwards shot 14 of 28 from the floor and 5 of 10 from three-point range in the victory.
Minnesota forward Julius Randle also played well on Wednesday. In 37 minutes, the former New York Knick logged 19 points, 7 rebounds, 6 assists, a blocked shot, and 2 steals. The former McDonald’s All-American shot 7 of 13 from the field and 3 of 5 from long range in the win.
Los Angeles Lakers Daily Fantasy Spin
Lakers forwards LeBron James (sciatica), Maxi Kleber (oblique), and Adou Thiero (knee) will all sit out Friday’s home date with the Timberwolves. James is the biggest loss of that trio, and is targeting mid-November for a potential return. The 4-time league MVP was the Lakers’ third-leading scorer last season with 24.4 points per game.
With James out of the lineup, Lakers head coach JJ Redick elected to elevate point guard Gabe Vincent to the starting lineup against the Warriors on Tuesday. Vincent only posted 3 points, 1 assist, and 1 steal in 29 minutes of game action in that contest. As a result, the Lakers could allot more minutes to forward Jake LaRavia or shooting guard Marcus Smart instead of Vincent on Friday.
Timberwolves vs. Lakers NBA Betting Trends
Minnesota is 7-3 ATS in their last 10 games against Los Angeles.
Minnesota is 6-4 ATS in their last 10 games overall.
Los Angeles is 1-6 ATS in their last 7 games overall.
Los Angeles is 9-11 ATS when playing with the rest advantage since the start of last season.
Timberwolves vs. Lakers NBA Prediction:
I like Minnesota here. A few numbers will illustrate why. The Timberwolves are 9-7 ATS when playing with the rest disadvantage and 37-31 ATS in conference games since the beginning of last season. What’s more, Minnesota is 53-46 ATS as the road team and 61-59-3 ATS when playing on 1 day of rest since the start of the 2023 season. I think the Timberwolves are the deeper team, and that depth is why they’ll win by 3 points or more on Friday. The pick is Minnesota -2.5 points over Los Angeles at Bovada.lv.