Last Updated on September 6, 2025 9:17 pm by Anthony Rome
In this Titans vs Broncos prediction, Tennessee heads west as a sizable underdog against a Denver team with playoff expectations. The Titans lean on Derrick Henry’s power and Will Levis’ steady improvement, while the Broncos are banking on Bo Nix’s poise in Sean Payton’s system. With a low total and Denver laying more than a touchdown, bettors must decide whether Tennessee’s grind-it-out style can keep the game within reach.
Titans vs. Broncos Event Information
- Matchup: Tennessee Titans at Denver Broncos
- Date: Sunday, September 7, 2025
- Time: 4:25 p.m. ET
- Stadium: Empower Field at Mile High — Denver, CO
- TV: CBS
Titans vs Broncos Betting Odds
Odds via Bovada:
- Spread: Titans +8
- Moneyline: Titans +285 / Broncos -360
- Total (O/U): 42.5
Public betting splits can be tracked at The Spread’s NFL public betting chart. Early reports show the public leaning toward Denver on the spread, while some sharp bettors are eyeing Tennessee with the points in what could be a slower-paced contest.
Titans’ Offense vs. Broncos’ Defense
The Titans remain committed to Derrick Henry, whose bruising style can slow down games and keep opposing offenses off the field. QB Will Levis enters his second year with better chemistry with WR DeAndre Hopkins, and Tennessee will need explosive plays off play-action to stay competitive.
Denver’s defense, anchored by Patrick Surtain II in the secondary, is built to eliminate WR1s. Their challenge will be handling Henry at altitude without overcommitting safeties, leaving them exposed to Hopkins downfield.
Broncos’ Offense vs. Titans’ Defense
Rookie QB Bo Nix takes the reins for Denver. His accuracy and composure fit Sean Payton’s system, which thrives on quick reads, short completions, and controlled tempo. The Broncos will mix in RB Javonte Williams to soften Tennessee’s front seven and keep Nix in manageable downs.
The Titans’ defensive strength is their line, with Jeffery Simmons wreaking havoc inside. If they can pressure Nix without blitzing, Denver may struggle to finish drives with touchdowns instead of field goals.
Key Matchups to Watch
- Derrick Henry vs. Broncos’ front seven – Can Denver withstand Henry’s physicality for four quarters at altitude?
- DeAndre Hopkins vs. Patrick Surtain II – Elite receiver vs. elite cornerback; Hopkins must win key third downs.
- Bo Nix vs. Titans’ disguised looks – Forcing rookie mistakes could keep Tennessee alive late.
- Red zone efficiency – With a total at 42.5, trips inside the 20 will decide whether this goes over or under.
Titans vs Broncos Prediction
The Broncos are rightfully favored, but an 8-point spread in a low-total game leaves room for Tennessee. Henry’s ability to control tempo and the Titans’ defensive front could frustrate Denver enough to make this a one-score contest. Denver’s rookie QB will do just enough to secure the win, but Tennessee grabs the cover.
Best Bets:
- Titans +8
- Under 42.5
Projected Score: Broncos 23, Titans 17