Will the Rams handle the Lions as a 6-point home favorite? Can the Packers halt the Broncos’ winning streak in Denver? Read on for our NFL Week 15 Best Predictions & Bets for the late slate in the NFL on Sunday.
NFL Week 15 Best Bet: Panthers -3
The 7–6 Carolina Panthers head to New Orleans to take on the 3–10 Saints in Week 15’s divisional NFC South matchup. Carolina enters this contest as a small favorite in most books and still has NFC South implications, while the Saints are playing to salvage pride and develop young players late in 2025.
Given Carolina’s edge in offensive balance, a rising run game, and an NFC South race still in play — combined with New Orleans’ defensive opportunism but offensive inconsistencies — this one projects as a close contest. However, I do like the Panthers to come out on top while also covering the field goal. They won’t take New Orleans lightly like they did in Charlotte earlier this season, plus the Falcons gave the Panthers an early Christmas gift on Thursday night by upsetting the Bucs. The NFC South is Carolina’s for the taking. Give me the Panthers -3.
NFL Week 15 Best Bet: Lions +6
Matthew Stafford and Jared Goff — once traded for each other — meet again in prime Week 15 spotlight. Stafford has been a MVP‑level producer for the Rams this season, combining efficiency and late‑game success. Goff’s Lions have taken key wins and are pushing for playoff relevance. Their matchup adds emotional spice and storyline depth.
This game shapes up as an NFC classic: two complementary offenses, high stakes for seeding, and contrasting strengths. L.A.’s depth and scoring efficiency, combined with Detroit’s secondary injuries, give the Rams a slight edge — but the Lions’ offensive firepower and playoff urgency keep this one close. Give me the Lions +6.
NFL Week 15 Best Bet: Packers -2.5
This Week 15 clash between the 9‑3‑1 Green Bay Packers and the 11‑2 Denver Broncos has playoff implications and a marquee feel — even though it’s “just” mid‑December. Both teams are riding winning streaks (Packers four straight, Broncos ten straight), and this could be one of the most compelling games of the weekend nationally.
This shapes up as one of Week 15’s best games — two hot teams with playoff positioning on the line. Denver’s home field, defensive strength, and special teams danger make this a rock‑fight, but the Packers’ recent form and offensive balance give them a slight edge in a close one. Give me the Packers -2.5.
Numbers update frequently — check the latest on the NFL public betting chart and learn usage basics in our public betting guide.
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