Game Information
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Date & Time: Sunday, October 26, 2025 — kickoff at 4:25 p.m. ET (3:25 p.m. CT) at Lucas Oil Stadium in Indianapolis.
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Teams: Tennessee Titans (1-6) at Indianapolis Colts (6-1)
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Context: Divisional matchup, Titans still searching for consistency; Colts riding a strong start. Indianapolis has won the last 5 meetings vs. Tennessee.
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Titans vs Colts Betting Odds & Public Betting
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Spread: Colts favored by 14.5 points. (Titans +14.5)
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Total (Over/Under): Around 47 points. Some sources list 47.5
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Moneyline & implied probabilities: Colts heavy favorites — one source gives them ~90% win probability.
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Angle for bettors: The Titans are getting a big number; the total is moderate for an anticipated imbalance matchup.
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Injury Report
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Titans:
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L’Jarius Sneed (CB) – Questionable with a quadriceps issue.
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Jeffery Simmons (DT) – Questionable, hamstring.
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Calvin Ridley (WR) – Inactive (hamstring) for Indy game.
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Colts:
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Samson Ebukam (DE) – Questionable (knee).
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Tyquan Lewis (DE) – Questionable (groin).
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Some inactives via coach’s decision (offensive line TE).
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Impact: The Titans are missing key offensive firepower and have defensive questions; the Colts remain relatively healthy but may be missing rotational depth. The health edge tilts toward Indianapolis.
(Always check final Friday/Saturday reports before locking action — injuries and practice designations move the market.)
Titans vs Colts News & Notes
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Tennessee has been plagued by penalties this season — 23 accepted thus far, the most in the NFL across offense, defense and special teams.
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The Titans’ offense continues to struggle under rookie quarterback Cam Ward and has shown limited ability to sustain drives.
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The Colts’ offense, led by Daniel Jones and Jonathan Taylor, is among the most efficient in the league so far, making this matchup particularly daunting for Tennessee.
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In the most recent meeting earlier this season, the Colts routed the Titans 41-20 in Nashville — a sign of dominance in the series.
Weather Report
Since the game is at Lucas Oil Stadium (an indoor venue), weather should not be a major factor. Expect standard indoor conditions — no wind, rain or extreme elements affecting play. Bettors can treat this as a climate-controlled environment.
Titans vs Colts Prediction
Given the overwhelming data: the Colts’ superior offense, the Titans’ struggles, large spread and previous head-to-head results — the expectation is Indianapolis covers the 14.5-point spread. The total of 47 is moderate; while the Colts can score, Tennessee may not be able to keep up or contribute enough, which could pull the total under.
My predicted final score: Colts 31, Titans 13
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Spread outcome: Colts cover comfortably
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Total: 44 points — under the 47 mark
Best bets:
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Take Colts –14.5
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Consider Under 47
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