Jaguars vs. Broncos NFL Picks & Predictions: Is Denver on Upset Alert?

Jaguars vs. Broncos Jaguars vs. Broncos

Will the Broncos keep rolling and hold onto the No. 1 seed in the AFC with a victory over the Jaguars? Or will Jacksonville secure a small upset in Sunday’s Jaguars vs. Broncos clash at 3:05 p.m. ET?

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Jaguars vs. Broncos Game Day Information

  • Matchup: Jacksonville Jaguars (10–4) at Denver Broncos (12–2)

  • Date & Time: Sunday, December 21, 2025 — 4:05 PM ET / 2:05 PM MT

  • Location: Empower Field at Mile High — Denver, Colorado

  • TV: FOX

Jaguars at Broncos — Week 16 Odds
Team
Spread
Total
Moneyline
Jacksonville Jaguars
+3.5
Over 47
+150
Denver Broncos
-3.5
Under 47
-180

Opening line: Jaguars +3 / Broncos -3

Key Stats & Storylines

Jaguars (10–4)

  • Jacksonville has surged with a 5-game win streak heading into Denver.

  • Trevor Lawrence leads a dynamic offense with over 3,200 passing yards and 23 TDs this season.

  • Travis Etienne Jr. is a versatile offensive weapon with nearly 950 rushing yards and a team-high in touchdowns.

  • Wideout Jakobi Meyers has provided a major boost since joining midseason.

  • Rookie RB Bhayshul Tuten is out due to surgery, which could limit depth behind Etienne.

  • Defensive playmakers like LB Devin Lloyd anchor a unit that creates turnovers.

Broncos (12–2)

  • Denver tops the AFC with an 11-game win streak and is undefeated at home.

  • QB Bo Nix has been efficient, throwing more than 3,200 yards and mixing well with his weapons.

  • Nik Bonitto and Denver’s pass rush rank among the league’s best, creating pressure and chaos for opposing QBs.

  • Broncos have dealt with RB J.K. Dobbins’s absence and leaned on depth like RJ Harvey in the backfield.

Team Stats Snapshot

  • Jaguars average ~26–27 PPG; Broncos ~24–26 PPG.

  • Denver’s defense ranks elite in limiting rush yards and points allowed.

Public Betting Tickets

Jaguars at Broncos — Who is The Public Betting?
Team
Tickets
Spread Movement (Open → Current)
Jacksonville Jaguars
42%
+3 → +3.5
Denver Broncos
58%
+3 → -3.5

Numbers update frequently — check the latest on the NFL public betting chart and learn usage basics in our public betting guide.

Jaguars vs. Broncos Picks & Predictions

This AFC clash projects as a high-stakes showdown with playoff implications for both teams. Jacksonville’s explosive offense and streaky play make them dangerous, but Denver’s stifling defense and home-field advantage give them the edge. I’m backing the Broncos to control the game in key moments and secure a home victory in a competitive contest.

Final Score Prediction: Broncos 27, Jaguars 21 (Take Denver -3)

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