The Miami Dolphins travel to Indianapolis on Sunday, September 7, 2025, to face the Colts in a Week 1 AFC matchup. This Dolphins vs Colts NFL preview covers updated betting odds, injury reports, public betting splits, and matchup notes as both teams aim to start their season with a statement victory.
Dolphins vs Colts Game Details
Date/Time, Location & TV
- Date & Time: Sunday, September 7, 2025 — 1:00 p.m. ET
- Location: Lucas Oil Stadium, Indianapolis, Indiana
- TV/Streaming: CBS
Dolphins vs Colts Betting Odds (via Bovada)
- Point Spread: Dolphins –2.0 | Colts +2.0
- Moneyline: Dolphins –125 | Colts +105
- Total (Over/Under): 47.0 — Over (–110), Under (–110)
Public Betting Snapshot
Early action shows the public leaning toward Miami on both the spread and moneyline, with bettors expecting the Dolphins’ explosive passing attack to set the tone. Totals betting has tilted slightly toward the Over, reflecting confidence in both offenses.
👉 Track updated splits here: NFL Public Betting Chart
News, Notes & Storylines
- Tua & Tyreek Show: Tua Tagovailoa and Tyreek Hill return as one of the NFL’s most dangerous QB-WR duos, looking to light up Indy’s secondary.
- Richardson’s Growth: Second-year QB Anthony Richardson brings athletic upside to the Colts, who are hoping for a big leap in his development.
- Run Game Impact: Jonathan Taylor anchors Indianapolis’ offense and could control tempo against a fast but sometimes vulnerable Miami defense.
- Miami’s Defense Reloaded: With key offseason acquisitions, the Dolphins are aiming to be more balanced on both sides of the ball.
Injury Report
- Miami Dolphins: WR Jaylen Waddle (questionable, hamstring); CB Jalen Ramsey (probable).
- Indianapolis Colts: RB Jonathan Taylor (probable); DE Kwity Paye (questionable, ankle).
Dolphins vs Colts Betting Trends
- ATS (Against The Spread): Dolphins are 5-2 ATS in their last 7 season openers.
- O/U (Totals): Over has hit in 4 of the last 6 Colts home games.
- Line Movement: Opened Dolphins –1, moved slightly to –2 with Miami support.
- Public Betting: Majority backing Dolphins spread and Over.
Recent Dolphins vs Colts Meetings
- 2024: Did not play
- 2023: Dolphins 24–17 (Miami)
- 2021: Colts 27–17 (Indianapolis)
Final Thoughts on Dolphins vs Colts
This matchup pits Miami’s high-octane passing game against an Indianapolis squad aiming to lean on a power rushing attack and home-field advantage. Expect Miami to push tempo through the air while the Colts counter with a ground-and-pound approach.
Key Storylines for Bettors
- Can Anthony Richardson protect the football against Miami’s pressure defense?
- Will Jonathan Taylor control the pace and keep Tua off the field?
- Can Miami’s speed overwhelm the Colts’ secondary indoors at Lucas Oil Stadium?
Bet Considerations:
- Spread: Lean Dolphins –2.0, as their aerial firepower should provide enough separation.
- Total: Lean Over 47.0, with both teams capable of explosive plays and quick scores.
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Dolphins vs Colts Snapshot
| Detail | Info |
|---|---|
| Date & Time | Sunday, Sept 7, 2025 — 1:00 p.m. ET |
| Location | Lucas Oil Stadium, Indianapolis, IN |
| TV | CBS |
| Spread | Dolphins –2.0 / Colts +2.0 |
| Moneyline | Dolphins –125 / Colts +105 |
| Total (O/U) | 47.0 points |
| Public Betting | Majority on Dolphins & Over |
| Series History | Split last two meetings (2021, 2023) |
| Trends | Dolphins strong in openers; Colts trend Over at home |
| Injuries | MIA: Waddle Q. IND: Taylor Probable |