The Colts vs. Jaguars matchup on Sunday shapes up as an AFC South clash with divisional control and playoff positioning on the line. This one should be physical and close — Jacksonville’s home edge meets Indianapolis’ balanced attack, and the matchup will come down to trench battles, turnover avoidance and late-game execution. The preview below breaks down game plans, key matchups, injury notes, weather and my final score projection.
Colts vs. Jaguars Game Day Information
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Date & time: Sunday, December 7, 2025 — 1:00 PM ET / 12:00 PM CT.
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Location: EverBank Stadium — Jacksonville, FL.
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TV: National afternoon window (check local listings).
Opening line: Colts +0.5/Jaguars -0.5
How Each Team Wins (Game Plans)
Colts — Manage the clock, take what the defense gives: Indianapolis will try to balance the run and short-to-intermediate passing to control tempo. Getting explosive plays from play-action and moving the pocket will be key if the Colts want to keep Jacksonville’s pass rush from dictating the game.
Jaguars — Own the line and force mistakes: Jacksonville will aim to win up front on both sides of the ball, generate pressure without gambling, and use a physical run game to shorten drives. If the Jaguars can create one or two takeaways and flip field position, that should be enough in a close AFC South fight.
Key Matchups to Watch
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Jaguars front seven vs. Colts interior run game: If Jacksonville can clog running lanes and force third-and-long, they’ll take Indy out of comfortable down-and-distance calls.
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Colts offensive line vs. Jaguars edge pressure: Protection and timing are crucial — Colts’ quarterback must have a clean pocket to hit intermediate targets and work the tempo.
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Tight ends and short-area receiving: Whoever wins the contested catch battle over the middle will control third-down conversions and red zone looks.
Public Betting Tickets
Numbers update frequently — check the latest on the NFL public betting chart and learn usage basics in our public betting guide.
Weather
Jacksonville in early December is usually mild; a dry, slightly warm afternoon favors cleaner passing and a faster pace. If rain appears, it will push both teams toward more conservative, run-heavy game plans.
Colts vs. Jaguars Picks & Predictions
This should be a tightly contested AFC South slugfest. I expect Jacksonville’s home edge and front-seven play to be the difference in a one-possession game.
Score projection: Jacksonville Jaguars 24, Indianapolis Colts 21.
How it plays out: A slow early pace turns into a late fourth-quarter exchange; the Jaguars make one defensive stand late and a short scoring drive seals it.
The Pick: Jaguars +1.5
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