Colts vs. Cardinals NFL Prediction

Colts vs. Cardinals, 12/25/21 NFL Christmas Day Betting Predictions

The second game of the NFL Christmas Day double header will take place in Arizona between a pair of postseason teams when the Cardinals host the Colts at 8:15 p.m. ET. Will Indianapolis pull off the upset or will Arizona rebound from its embarrassing loss to the Lions?

Game Snapshot

455 Indianapolis Colts (+2.5) at 456 Arizona Cardinals (-2.5); o/u 48.5

8:15 p.m. ET, Saturday, December 25, 2021

State Farm Stadium, Glendale, AZ

TV: NFL Network

Indianapolis Colts DFS Spin

Colts placed LG Quenton Nelson on the reserve/COVID list. Already without C Ryan Kelly because of a personal matter and RG Mark Glowinski (COVID), it looks like the Colts will be without their star left guard as well. Those losses represent a big downgrade for Jonathan Taylor, although at this point there does appear to be anything that can slow him down. He will remain a high-end RB1.

Arizona Cardinals DFS Spin

James Conner (heel, questionable) is "confident" he will suit up against the Colts on Saturday. Injured players are always confident they will play right up until the second they don't, but it is notable nonetheless. Conner said it's an issue of pain management with his heel, and that there are no lingering issues with his ankle. With the Cardinals' season suddenly headed the wrong direction, they will undoubtedly lean toward having Conner go, but there's a chance it just won't be feasible based on how he feels in pre-game warmups. Conner is a real-deal game-time call. Chase Edmonds and Eno Benjamin will form a committee if Conner sits, with Edmonds probably getting enough work to be an RB2.

NFL Week 16 Betting Prediction

The Colts are 5-0 against the spread in their last five road games, are 4-1 against the number in their last five games as an underdog and have covered in seven of their last nine games after allowing more than 350 total yards in their previous game. The Cardinals, meanwhile, are 9-23 against the spread in their last 32 games as a home favorite, are 3-8 against the number in their last 11 home games and are 1-4 ATS in their last five games as a favorite.

NFL WEEK 16 PREDICTION: INDIANAPOLIS COLTS +2.5

Recent NFL Discussions

NFL Predictions & Picks

Thumbnail Kenneth Gainwell Prop Prediction Kenneth Gainwell went off against the Giants in the Divisional Round of the NFL playoffs and then contributed in the Eagles’ NFC title win over the...
Thumbnail Quez Watkins Super Bowl Prop Prediction It’s officially Super Bowl week and we’re starting off our prop predictions with a look at Eagles’ receiver Quez Watkins. How much of an impact will Watkins...
Thumbnail Best NFL Players Not in the Hall of Fame Not so long ago, the NFL Hall of Fame was replenished with eight more names of the best football players of all time.
Thumbnail 49ers vs. Eagles Prediction & Odds The Eagles will be slight favorites when they host the 49ers in the NFC Championship Game on Sunday at 3:00 p.m. ET. Even with a rookie under center, is San...
Thumbnail NFC Championship Game Total Prediction The total for Sunday’s NFC Championship Game between the 49ers and Eagles opened at 45.5 but has been bet up to 46.5.

NFL Headlines