49ers vs. Bengals Prediction

49ers vs. Bengals, 12/12/21 NFL Week 14 Betting Predictions & Odds

A pair of playoff hopefuls will meet in Cincinnati on Sunday when the Bengals host non-conference opponent San Francisco at 4:25 p.m. ET. Are the Niners the wise play or is there a better bet on the board?

Game Snapshot

109 San Francisco 49ers (-1.5) at 110 Cincinnati Bengals (+1.5); o/u 49

4:25 p.m. ET, Sunday, December 12, 2021

Paul Brown Stadium, Cincinnati, OH

TV: CBS

San Francisco 49ers DFS Spin

ESPN's Adam Schefter reports Deebo Samuel (questionable, core) will return for Week 14 vs. the Bengals. Samuel got in only one limited practice this week, but he will return to the 49ers' receiver corps and backfield after missing just one game. Samuel was injured on a carry two weeks ago when he tried to stop his own momentum in the red zone, but the 49ers figure to go right back to his multi-dimensional usage with Elijah Mitchell (concussion) on the shelf. Perhaps Samuel will have his snaps dialed back ever so slightly, but he can be trusted as a WR1. His return dings Brandon Aiyuk's WR2 outlook and will lower George Kittle's targets floor after Kittle's Week 13 outburst in Samuel's absence.

Cincinnati Bengals DFS Spin

NFL Network's Ian Rapoport reports Joe Mixon (illness) is expected to play in Week 14 against the 49ers. Mixon didn't practice all week but non-COVID illnesses are typically easy to bounce back from. As long as he's feeling good, Mixon is in line for another RB1 outing. He has scored in nine consecutive games and is averaging 25.7 carries per game since the Bengals' bye week. Even against a tough San Francisco defense, fantasy managers can trust Mixon for elite fantasy numbers.

NFL Week 14 Betting Prediction

The road team is 3-1-1 against the spread in the last five meetings between these two teams, while the 49ers are 3-1-1 against the number in the last five meetings against the Bengals. Cincinnati, meanwhile, is 3-11 against the spread in its last 14 games when playing in Week 14, is 1-4 against the number in its last five home games and is 1-7 against the spread in its last eight games after allowing more than 250 yards passing in its previous contest.

NFL WEEK 14 PREDICTION: SAN FRANCISCO 49ERS -1.5

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